Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Decreased expression of the calcium-binding protein calbindin-D<sub>28K</sub> (CB) might be a susceptibility factor for AD.
|
31668966 |
2020 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ, and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus.
|
29573847 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two months of CSP consumption reversed spatial memory deficits and the loss of a calcium binding protein calbindin-D<sub>28k</sub> in the hippocampus of AD mouse model.
|
29535835 |
2018 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heterochronic parabiosis (shared blood circulation) of AD transgenic mice with young healthy mice did not reduce amyloidosis and microglial activation in AD mice, but reversed the loss of synaptophysin and calbindin (critical synaptic proteins, indicators of cognitive decline in AD) in the dentate gyrus, and the abnormal expression, in the hippocampus, of many genes involved in key neuronal signaling pathways.
|
28384033 |
2018 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, levels of ΔFosB and calbindin expression are inversely related in the DG of individuals with temporal lobe epilepsy (TLE) or AD and correlate with performance on the Mini-Mental State Examination (MMSE).
|
29035369 |
2017 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have shown that most of the BFCN in the human brain contain the calcium-binding protein calbindin-D28K (CB), a large proportion lose their CB in the course of normal aging, and the BFCN which degenerate in AD lack CB.
|
26417681 |
2015 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using basal forebrain cholinergic neurons (BFCNs) as a model and immunohistochemistry, we have demonstrated significant age-related loss of the calcium-binding protein calbindin-D(28K) (CB) from BFCN, which was associated with tangle formation and degeneration in AD.
|
24461366 |
2014 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease.
|
20399254 |
2010 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Learning deficits in mice expressing familial AD-mutant hAPP correlated strongly with decreased levels of the calcium-binding protein calbindin-D28k (CB) and the calcium-dependent immediate early gene product c-Fos in granule cells of the dentate gyrus, a brain region critically involved in learning and memory.
|
12881482 |
2003 |
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ontogenetic expression of spot 35 protein (calbindin-D28k) in human olfactory receptor neurons and its decrease in Alzheimer's disease patients.
|
8659934 |
1996 |
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mRNA in the substantia nigra (Parkinson disease), in the corpus striatum (Huntington disease), in the nucleus basalis (Alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (Parkinson, Huntington, and Alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus.
|
2140897 |
1990 |