|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
BEFREE |
TRPV1 contributes to peripheral sensitization and hyperalgesia, in part, <i>via</i> triggering the release of proinflammatory peptides, such as calcitonin gene-related peptide (CGRP), both locally and at the dorsal horn of the spinal cord.
|
31551772 |
2019 |
|
Hyperalgesia
|
0.540 |
AlteredExpression
|
phenotype |
BEFREE |
Nevertheless, ghrelin modulated nitroglycerin-triggered changes in transient receptor potential vanilloid-1 and calcitonin gene-related peptide expression, and mitigated nitroglycerin-induced hyperalgesia.
|
29237283 |
2018 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
BEFREE |
Our study hypothesis is to evaluate the preventive value of epidural calcitonin on postoperative pain, grade of phantom pain, and the development of allodynia and hyperalgesia in patients undergoing lower limb amputation.
|
28100669 |
2017 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
|
Hyperalgesia
|
0.540 |
Therapeutic
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
RGD |
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
|
21958434 |
2011 |
|
Hyperalgesia
|
0.540 |
Therapeutic
|
phenotype |
CTD_human |
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
|
15265675 |
2004 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
BEFREE |
PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia.
|
15128844 |
2004 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
CTD_human |
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
|
15265675 |
2004 |
|
Hyperalgesia
|
0.540 |
Therapeutic
|
phenotype |
CTD_human |
The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin.
|
12855330 |
2003 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
CTD_human |
The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin.
|
12855330 |
2003 |
|
Hyperalgesia
|
0.540 |
Therapeutic
|
phenotype |
CTD_human |
Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain.
|
12787826 |
2003 |
|
Hyperalgesia
|
0.540 |
Biomarker
|
phenotype |
CTD_human |
Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain.
|
12787826 |
2003 |
|
Inflammation
|
0.500 |
Biomarker
|
phenotype |
RGD |
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
|
21958434 |
2011 |
|
Inflammation
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
|
11588175 |
2001 |
|
Migraine Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Galcanezumab is a humanized immunoglobulin G (IgG) monoclonal antibody (mAb) indicated for the prevention of migraine that binds to calcitonin gene-related peptide.
|
31482569 |
2020 |
|
Migraine Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Problematic presentation and use of efficacy measures in current trials of CGRP monoclonal antibodies for episodic migraine prevention: A mini-review.
|
31547694 |
2020 |
|
Migraine Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This is relevant as the recently licensed CGRP antagonists are likely to change current treatment schemes for migraine, which strongly depends also on the comorbidities.
|
31828875 |
2020 |
|
Migraine Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Galcanezumab is a monoclonal antibody that binds to calcitonin gene-related peptide and is indicated for preventive treatment of migraine.
|
31710104 |
2020 |
|
Migraine Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We explored the effects of PD-1 in a migraine model by the von Frey test and by analyzing the expression of calcitonin gene-related peptide, interleukin-1β (IL-1β), interleukin-18 (IL-18), Tumor Necrosis Factor-α (TNF-α), interleukin-6 (IL-6) and transient receptor potential vanilloid (TRPV4) after the intravenous injection of a PD-1 inhibitor.
|
31640402 |
2020 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Calcitonin (elcatonin [eCT]) has been used mainly for hypercalcemia and pain associated with osteoporosis.
|
30655691 |
2019 |
|
Hypercalcemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The patient had longstanding hypercalcaemia and hyperparathyrodism refractory to calcimimetics, calcitonin, hormone and haemodialysis.
|
31088386 |
2019 |
|
Hypercalcemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Twenty-one patients with EPNS were detected: 16 with ectopic Cushing's syndrome (ECS), one with hypercalcaemia due to parathyroid hormone-related protein (PTHrP) secretion, three with hypercalcitonaemia and one patient with dual secretion of calcitonin and beta-human chorionic gonadotropin (β-HCG).
|
30280284 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
CGRP, known as the most potent vasodilator substance, plays an important role in hypertension initiation and development.
|
30818175 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Calcitonin gene-related peptide (CGRP) can cause migraines, yet it is also a potent vasodilator that protects against hypertension.
|
29297736 |
2019 |