NEIL1, nei like DNA glycosylase 1, 79661

N. diseases: 59; N. variants: 5
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 GeneticVariation disease BEFREE To investigate this hypothesis, publicly-available data on variant alleles of NEIL1 were analyzed and compared with genome sequencing data from HCC tissues derived from individuals residing in Qidong County (China). 31100703 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 GeneticVariation disease BEFREE These data suggest that inactivating polymorphic variants of NEIL1 could be a potential driver of HCCs in aflatoxin-exposed populations. 30897375 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 Biomarker disease BEFREE Recently, we have demonstrated that the DNA glycosylase NEIL1 can initiate repair of AFB<sub>1</sub>-Fapy-dG adducts both in vitro and in vivo, with Neil1<sup>-/-</sup> mice showing an increased susceptibility to AFB<sub>1</sub>-induced hepatocellular carcinoma. 30448017 2019