Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
In the current study, we report that exposure to a chronic oxidative stress in the form of a high-fat diet greatly accelerates the development of obesity in neil1(-/-) mice.
|
21285402 |
2011 |
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Obesity
|
0.500 |
Biomarker
|
disease |
MGD |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Metabolic Syndrome X
|
0.310 |
Biomarker
|
disease |
CTD_human |
Extrapolation of these data suggests that individuals who are heterozygous for these inactive variant neil1 alleles may be at increased risk for metabolic syndrome.
|
17389588 |
2007 |
Metabolic Syndrome X
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Extrapolation of these data suggests that individuals who are heterozygous for these inactive variant neil1 alleles may be at increased risk for metabolic syndrome.
|
17389588 |
2007 |
Metabolic Syndrome X
|
0.310 |
Biomarker
|
disease |
CTD_human |
These data suggest an important role for NEIL1 in the prevention of the diseases associated with the metabolic syndrome.
|
16446448 |
2006 |
Fatty Liver
|
0.300 |
Biomarker
|
disease |
CTD_human |
Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(+/+) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis.
|
21285402 |
2011 |
Hyperlipidemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
|
21285402 |
2011 |
Insulin Resistance
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
|
21285402 |
2011 |
Impaired glucose tolerance
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
A long-term high-fat diet also induced glucose intolerance as well as a significant reduction in mitochondrial DNA and protein content in neil1(-/-) mice.
|
21285402 |
2011 |
Insulin Sensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
|
21285402 |
2011 |
Lipidemias
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
|
21285402 |
2011 |
Steatohepatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(+/+) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis.
|
21285402 |
2011 |
Fatty Liver
|
0.300 |
Biomarker
|
disease |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
CTD_human |
In the absence of exogenous oxidative stress, neil1 knockout (neil1-/-) and heterozygotic (neil1+/-) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia.
|
16446448 |
2006 |
Dyslipidemias
|
0.300 |
Biomarker
|
group |
CTD_human |
In the absence of exogenous oxidative stress, neil1 knockout (neil1-/-) and heterozygotic (neil1+/-) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia.
|
16446448 |
2006 |
Dyslipoproteinemias
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Endogenous Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Exogenous Hyperinsulinism
|
0.300 |
Biomarker
|
disease |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Compensatory Hyperinsulinemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Steatohepatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
|
16446448 |
2006 |
Abdominal obesity metabolic syndrome
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We suggest that individuals who harbor the G83D NEIL1 variant face an increased risk for human cancer.
|
29156764 |
2017 |
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We suggest that individuals who harbor the G83D NEIL1 variant face an increased risk for human cancer.
|
29156764 |
2017 |
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
As a mechanism underlying the reduced expression of NEIL1 in cancer, the epigenetic silencing of NEIL1 through promoter hypermethylation was found.
|
27042257 |
2016 |