|
Ectodermal Dysplasia
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that four mechanisms may participate in the regulation of the PAD gene and could be of relevance for the progression of amyloid deposition in Alzheimer's disease.
|
3053167 |
1988 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
The authors concluded that the most important methods of prevention of atherosclerosis in youth should be: identification of high-risk individuals (overweight, hypertension, hyperlipidemia, family history of CHD and PAD, ischemic postexercise ST segment depression), health education and motivation for change, modification nutritional habits in cases of hyperlipidemia and overweight (prevention of early atherosclerotic lesions in childhood), early diagnosis and control of hypertension, practice of low salt intake, avoidance of smoking, sufficient physical activity (prevention of atherosclerotic disease mainly in adulthood).
|
2212795 |
1990 |
|
Atherosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
The authors concluded that the most important methods of prevention of atherosclerosis in youth should be: identification of high-risk individuals (overweight, hypertension, hyperlipidemia, family history of CHD and PAD, ischemic postexercise ST segment depression), health education and motivation for change, modification nutritional habits in cases of hyperlipidemia and overweight (prevention of early atherosclerotic lesions in childhood), early diagnosis and control of hypertension, practice of low salt intake, avoidance of smoking, sufficient physical activity (prevention of atherosclerotic disease mainly in adulthood).
|
2212795 |
1990 |
|
Hypertensive disease
|
0.030 |
Biomarker
|
group |
BEFREE |
The authors concluded that the most important methods of prevention of atherosclerosis in youth should be: identification of high-risk individuals (overweight, hypertension, hyperlipidemia, family history of CHD and PAD, ischemic postexercise ST segment depression), health education and motivation for change, modification nutritional habits in cases of hyperlipidemia and overweight (prevention of early atherosclerotic lesions in childhood), early diagnosis and control of hypertension, practice of low salt intake, avoidance of smoking, sufficient physical activity (prevention of atherosclerotic disease mainly in adulthood).
|
2212795 |
1990 |
|
Hyperlipidemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The authors concluded that the most important methods of prevention of atherosclerosis in youth should be: identification of high-risk individuals (overweight, hypertension, hyperlipidemia, family history of CHD and PAD, ischemic postexercise ST segment depression), health education and motivation for change, modification nutritional habits in cases of hyperlipidemia and overweight (prevention of early atherosclerotic lesions in childhood), early diagnosis and control of hypertension, practice of low salt intake, avoidance of smoking, sufficient physical activity (prevention of atherosclerotic disease mainly in adulthood).
|
2212795 |
1990 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
When injected in human breast cancer xenografts, pAd-T34A inhibited growth of established tumors and triggered tumor cell apoptosis in vivo.
|
12855648 |
2003 |
|
Cardiovascular Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Cardiovascular disease is prevalent in first-degree relatives of young adults with premature-onset peripheral arterial occlusive disease (premature PAD), but it is not known whether the genetic influence is independent of other risk factors, the most prevalent of which is smoking.
|
14743135 |
2004 |
|
Peripheral arterial occlusive disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cardiovascular disease is prevalent in first-degree relatives of young adults with premature-onset peripheral arterial occlusive disease (premature PAD), but it is not known whether the genetic influence is independent of other risk factors, the most prevalent of which is smoking.
|
14743135 |
2004 |
|
Peripheral Arterial Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, the association between these genetic disorders and the three main arterial complications (myocardial infarction [MI], ischemic stroke [IS], and peripheral arterial disease [PAD]) is modest.
|
17433903 |
2007 |
|
Peripheral Vascular Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Overall, the association between these genetic disorders and the three main arterial complications (myocardial infarction [MI], ischemic stroke [IS], and peripheral arterial disease [PAD]) is modest.
|
17433903 |
2007 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
BEFREE |
We reported that peptidylarginine deiminase (gene name abbreviated to PADI, protein name abbreviated to PAD) type 4 is the one of the non-HLA genetic factors involved in RA via citrullination.
|
17893996 |
2007 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for age, gender, traditional cardiovascular risk factors, and CAD, PAD and CVD, ACE DD genotype still affected the susceptibility to AAA [OR=2.13 (95% CI 1.06-4.28), p=0.03], and the contemporary presence of ACE DD genotype and TGFBR1 6A allele, increased the predisposition to the disease [OR=5.09 (95% CI 1.44-18.02), p=0.01].
|
18550062 |
2009 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
BEFREE |
To define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA).
|
21859690 |
2012 |
|
Cerebrovascular accident
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Overall microangiopathy (retinopathy, neuropathy and/or nephropathy) was present in 74%, and overall macroangiopathy (CAD, PAD and/or TIA/stroke) in 45%.
|
22224829 |
2012 |
|
Multiple Sclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Peptidylarginine deiminase 2 (PAD2) and peptidylarginine deiminase 4 (PAD4) are two members of PAD family which are over-expressed in the multiple sclerosis (MS) brain.
|
21878453 |
2012 |
|
Peripheral Vascular Diseases
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Microvascular complications were more frequent in the PAD and PVD patients.
|
23331854 |
2013 |
|
Arteriosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Little is known about whether the four main manifestations of arterial vascular disease (coronary heart disease = CHD, ischemic stroke, peripheral artery disease = PAD, and aortic (i.e. atherosclerosis/aneurysm) disease = AD) share familial susceptibility.
|
23642611 |
2013 |
|
Atherosclerosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Little is known about whether the four main manifestations of arterial vascular disease (coronary heart disease = CHD, ischemic stroke, peripheral artery disease = PAD, and aortic (i.e. atherosclerosis/aneurysm) disease = AD) share familial susceptibility.
|
23642611 |
2013 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
In the multivariate analysis, age, male sex and diabetes duration were independent risk factors for PAD and PVD (P < 0.01).
|
23331854 |
2013 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
In the multivariate analysis, age, male sex and diabetes duration were independent risk factors for PAD and PVD (P < 0.01).
|
23331854 |
2013 |
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
Standardized incidence ratios (SIRs) for CHD (n = 140,708 cases), ischemic stroke (n = 73,771), PAD (n = 18,982) and AD (n = 7879) were calculated for siblings of individuals hospitalized due to CHD, stroke, PAD or AD compared to those of unaffected siblings.
|
23642611 |
2013 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
The highest sibling risks were observed for premature concordant disease (<55 years for males and <65 years for females): SIR for CHD = 1.93 (95% CI: 1.90-1.96), SIR for ischemic stroke = 1.45 (1.39-1.50), SIR for PAD = 2.76 (2.54-3.00), and SIR for AD = 6.36 (5.28-7.59).
|
23642611 |
2013 |
|
Peripheral Arterial Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Peripheral artery disease (PAD) generates tissue ischemia through arterial occlusions and insufficient collateral vessel formation.
|
25362254 |
2014 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
From this study it can be concluded that if P. gingivalis plays a role in RA, it is unlikely to originate from a variation in PPAD gene expression.
|
26403779 |
2015 |