|
Rheumatoid Arthritis
|
0.440 |
Biomarker
|
disease |
BEFREE |
Further efforts are needed to replicate the genome-wide significant association with ANKRD55-associated in prior research with several autoimmune and inflammatory disorders-and to clarify the nature of the genetic overlap observed between PTSD and rheumatoid arthritis and psoriasis.
|
27167565 |
2016 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
The ankyrin repeat domain-55 (<i>ANKRD55</i>) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders.
|
31620119 |
2019 |
|
Rheumatoid Arthritis
|
0.440 |
Biomarker
|
disease |
BEFREE |
We confirmed the known markers ANKRD55 (meta-analysis odds ratio [OR] 0.80; P = 2.8 × 10(-13) ) and BLK (OR 1.13; P = 7.0 × 10(-6) ) and identified new and specific markers of anti-CCP-negative RA (prolactin [PRL] [OR 1.13; P = 2.1 × 10(-6) ] and NFIA [OR 0.85; P = 2.5 × 10(-6) ]).
|
26895230 |
2016 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
The first SNP, rs6859219, located in ANKRD55 (Chr5), was recently discovered in a meta-analysis of GWAS on rheumatoid arthritis (RA), and emerged from this study with genome-wide significance (odds ratio (OR) = 1.35; P = 2.3 × 10(-9)).
|
22130326 |
2012 |
|
Autoimmune Diseases
|
0.120 |
GeneticVariation
|
group |
BEFREE |
As an example, we found that rs71624119, shared with three other autoimmune diseases and located in a primed enhancer (H3K4me1) with potential binding for STAT transcription factors, significantly associates with ANKRD55 expression.
|
29325110 |
2018 |
|
Autoimmune Diseases
|
0.120 |
GeneticVariation
|
group |
BEFREE |
The ankyrin repeat domain-55 (<i>ANKRD55</i>) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders.
|
31620119 |
2019 |
|
Multiple Sclerosis
|
0.120 |
Biomarker
|
disease |
BEFREE |
Together, these data support an important role for ANKRD55 in multiple sclerosis and neuroinflammation.
|
27183579 |
2016 |
|
Multiple Sclerosis
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
The ankyrin repeat domain-55 (<i>ANKRD55</i>) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders.
|
31620119 |
2019 |
|
Psoriasis
|
0.110 |
Biomarker
|
disease |
BEFREE |
Further efforts are needed to replicate the genome-wide significant association with ANKRD55-associated in prior research with several autoimmune and inflammatory disorders-and to clarify the nature of the genetic overlap observed between PTSD and rheumatoid arthritis and psoriasis.
|
27167565 |
2016 |
|
Post-Traumatic Stress Disorder
|
0.110 |
Biomarker
|
disease |
BEFREE |
Further efforts are needed to replicate the genome-wide significant association with ANKRD55-associated in prior research with several autoimmune and inflammatory disorders-and to clarify the nature of the genetic overlap observed between PTSD and rheumatoid arthritis and psoriasis.
|
27167565 |
2016 |
|
Juvenile arthritis
|
0.110 |
Biomarker
|
disease |
BEFREE |
SNPs in or near PTPN22, VTCN1, the IL2-IL21 region, ANKRD55 and TNFA were confirmed to be associated with JIA (p<0.05), strengthening the evidence for involvement of these genes in JIA.
|
25057181 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort.
|
23457408 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genome-wide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, and BCAR1.
|
25951451 |
2015 |
|
Dermatomyositis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In CD4+ T cells, only two genes, ANKRD55 and S100B, were expressed significantly higher in patients with PM than in patients with DM (false discovery rate [FDR] < 0.05, model adjusted for age, sex, HLA-DRB1*03 status, and RNA integrity number [RIN]).
|
30157932 |
2018 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ANKRD55 protein was increased in the murine mouse model of experimental autoimmune encephalomyelitis.
|
27183579 |
2016 |
|
Adult type dermatomyositis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In CD4+ T cells, only two genes, ANKRD55 and S100B, were expressed significantly higher in patients with PM than in patients with DM (false discovery rate [FDR] < 0.05, model adjusted for age, sex, HLA-DRB1*03 status, and RNA integrity number [RIN]).
|
30157932 |
2018 |
|
Rheumatoid Arthritis
|
0.440 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Chloracne
|
0.300 |
Biomarker
|
disease |
CTD_human |
Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects.
|
17101203 |
2007 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.
|
28706201 |
2017 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Rheumatoid Arthritis
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Juvenile pauciarticular chronic arthritis
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
|
23603761 |
2013 |