PALB2, partner and localizer of BRCA2, 79728

N. diseases: 260; N. variants: 410
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE Twenty-one genes showed single or cross-cancer associations, including novel associations of SDHA in melanoma and PALB2 in stomach adenocarcinoma. 29625052 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE Overall our data do not support a case for PALB2 being associated with melanoma predisposition. 24949998 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.150 GeneticVariation disease BEFREE Such subsets of familial pancreatic cancer involve germline cationic trypsinogen or PRSS1 mutations (hereditary pancreatitis), BRCA2 mutations (usually in association with hereditary breast-ovarian cancer syndrome), CDKN2 mutations (familial atypical mole and multiple melanoma), or DNA repair gene mutations (e.g., ATM and PALB2, apart from those in BRCA2). 24395243 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE In addition, no significant associations were observed between 11 PALB2 tagging SNPs and melanoma risk in 23 melanoma-prone families with CDKN2A mutations or the subset of 11 families with PC or PC-related CDKN2A mutations. 21614589 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease BEFREE This functional relationship made PALB2 a candidate gene for susceptibility to BRCA2-related cancers such as melanoma. 21153565 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.150 CausalMutation disease CLINVAR
CUI: C0025202
Disease: melanoma
melanoma 		0.150 Biomarker disease HPO