Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
One tumor exhibited PALB2 LOH and RAD51 assay indicated homologous recombination deficiency in both tumors.
|
30552643 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The identification of BRCA1, BRCA2 and PALB2 as proteins involved in DNA double-strand break repair by homologous recombination and of the impact of complete loss of BRCA1 or BRCA2 within tumors have allowed the development of novel therapeutic approaches for patients with germline or somatic mutations in said genes.
|
31067289 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Herein, we review recent developments in our understanding of the mechanisms of regulation of the tumor suppressor PALB2 and its functional domains.
|
30638972 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BReast Cancer Associated proteins 1 and 2 (BRCA1, -2) and Partner and Localizer of BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia.
|
31017574 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA levels of CDK12, PALB2 and XPF inversely associated with the <i>in vivo</i> DDP antitumor activity; higher CDK12 mRNA levels were associated with a higher recurrence rate in ovarian patients with low residual tumor.
|
29872499 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The majority of cancers showed clear evidence of bi-allelic inactivation of PALB2 (10/15) either as loss of heterozygosity involving the wild-type allele (six tumours) or as somatic point mutations (four tumours).
|
29431189 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Despite no apparent genotype-phenotype trends, our data indicate that some loss-of-function variants in PALB2 may lead to differences in tumor behavior and patient outcome.
|
28709830 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Whole-exome sequencing of a breast cancer from a c.104T>C carrier revealed a second, somatic, truncating mutation affecting PALB2, and the tumor displays hallmark genomic features of tumors with BRCA mutations and HR defects, cementing the pathogenicity of L35P.
|
28319063 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BRCA2 and PALB2 are tumor suppressors implicated in cancer.
|
27974172 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif.
|
28158555 |
2017 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This case-control study provided evidence that rs120963 and rs249954 of the PALB2 gene are associated with increased breast cancer risk, and that the association of rs249935 with breast cancer risk may be modified by the tumor pathological characteristics.
|
26981788 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When levels of PALB2 mRNA were compared to histopathological data (tumor size, grade, lymph node involvement, metastasis, hormone receptors and HER2 overexpression), no significant statistical correlation was found.
|
26526077 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, including the mismatch repair (MMR) genes in Lynch syndrome, the tumor suppressor gene, TP53, in the Li-Fraumeni syndrome, and several other genes involved in the double-strand breaks repair system, such as CHEK2, RAD51, BRIP1, and PALB2.
|
26075229 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Next, PALB2 interacts with BRCA2, which is a tumor suppressor, and with the RAD51 recombinase.
|
24998779 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumour suppressor role of PALB2 has been intimately linked to its ability to promote HR (homologous recombination)-mediated repair of DNA double-strand breaks.
|
24870022 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Somatic mutations were identified in genes in which constitutional alterations are associated with familial pancreatic ductal adenocarcinoma, such as ATM, BRCA2 and PALB2 (one tumour each), as well as in genes altered in extra-pancreatic neoplasms, such as JAK1 in four tumours (17%), BRAF in three (13%), RB1 in three (13%), APC in two (9%), PTEN in two (9%), ARID1A in two (9%), MLL3 in two (9%) and BAP1 in one (4%).
|
24293293 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we show that similar to Brca1 and Brca2, ablation of Palb2 in the mouse mammary gland resulted in tumor development with long latency, and the tumors harbored mutations in Trp53.
|
23650262 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We screened the PALB2 p.Q775X variant in 71 families with at least three cases of breast cancer (n=48) or breast and ovarian cancers (n=23) that have previously been found negative for at least the most common BRCA1 and BRCA2 mutations reported in the French Canadian population and in 491 women of French Canadian descent who had invasive ovarian cancer and/or low malignant potential tumors of the major histopathological subtypes.
|
23302520 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumour morphological features of the 28 PALB2 mutation carriers were compared with those of 770 women without high-risk mutations.
|
23787919 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Given the prevalence, breast cancer risk, and tumour grade associated with this mutation, consideration of clinical PALB2 testing is warranted.
|
23448497 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To further understand the mechanisms underlying PALB2-mediated DNA repair and tumor suppression functions, we targeted Palb2 in the mouse.
|
23657012 |
2013 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In view of these similarities, we investigated whether the prevalence of PALB2 mutations was increased in breast cancer families with the occurrence of BRCA2 associated tumours other than female breast cancer.
|
20582465 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PALB2's tumor-suppressing effect is thought to be based on its ability to facilitate BRCA2's function in homologous recombination.
|
20871615 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair.
|
20871616 |
2010 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Carrying a PALB2 mutation was also associated with reduced survival, especially in familial cases (hazard ratio, 2.30; 95% CI, 1.01-5.24; P = 0.0466) and among familial patients with HER2-negative tumors (hazard ratio, 4.57; 95% CI, 1.96-10.64; P = 0.0004).
|
19383810 |
2009 |