Generalized hypotonia
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Dilated ventricles (finding)
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Broad jaw
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
CNS hypomyelination
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
PD-L1 positivity was prevalent in females, HPV-positive tumors without base of tongue invasion, and SNIP1-overexpressed tumors.
|
29634978 |
2018 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
High expression level of SNIP1 in tumor patients was significantly correlated with poor prognosis in NSCLC (log-rank P for OS = 0.01, log-rank P for DFS = 0.001).
|
23932364 |
2013 |
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
There was a selective requirement of PML isoform in NFAT activation: PML-I and PML-VI, but not PML-IV, increased NFAT transactivation.
|
18246125 |
2008 |
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Only the isoform-specific sequences of PML-I and PML-V are highly conserved between man and mouse.
|
16778193 |
2006 |
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
PML I was able to recruit AML1 and coactivator p300 in PML nuclear bodies and enhance the AML1-mediated transcription in the presence of p300.
|
15331439 |
2005 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Analysis of an additional 16 strains for which only the T-ag-C gene was sequenced indicated that further SV40 genetic diversity is likely, resulting in a provisional clade (clade C) that currently contains strains associated with human tumors and human strain PML-1.
|
15308725 |
2004 |
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
High expression of SNIP1 correlates with poor prognosis in non-small cell lung cancer and SNIP1 interferes with the recruitment of HDAC1 to RB in vitro.
|
23932364 |
2013 |
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis.
|
17157259 |
2006 |
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Targeting SNIP1 may provide a therapeutic approach for the treatment of IBD.
|
29426045 |
2018 |
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, PML-I and TSP2 expression inversely correlates with tumor angiogenesis and recurrence in localized neuroblastomas.
|
27076624 |
2016 |
Cancer Relapse
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our work reveals a novel PML-I-TSP2 axis for the regulation of angiogenesis and cancer relapse, which could be used to identify patients with low-risk, localized tumors that might benefit from chemotherapy.
|
27076624 |
2016 |
Tumor Angiogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, PML-I and TSP2 expression inversely correlates with tumor angiogenesis and recurrence in localized neuroblastomas.
|
27076624 |
2016 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings may indicate the involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.
|
23932364 |
2013 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings may indicate the involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.
|
23932364 |
2013 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings may indicate the involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.
|
23932364 |
2013 |
Squamous cell carcinoma of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is proposed that co-expression of more than two markers from HIF-1α, TWIST2 and SNIP1 might be a significant prognostic predictor in patients with TSCC.
|
21167768 |
2011 |
Fibroid Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma.
|
20651370 |
2010 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We obtained metastasized melanoma tissue from a primary acral lentiginous melanoma (ALM) patient and established a melanoma cell line named primary culture of melanoma cell derived from lymph node (PML)-1.
|
19759547 |
2010 |
Uterine Fibroids
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma.
|
20651370 |
2010 |
Acral Lentiginous Malignant Melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We obtained metastasized melanoma tissue from a primary acral lentiginous melanoma (ALM) patient and established a melanoma cell line named primary culture of melanoma cell derived from lymph node (PML)-1.
|
19759547 |
2010 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
This study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer.
|
18794151 |
2008 |