Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Overall, significant association was observed between the PSCA gene variant rs2294008 polymorphism and bladder cancer (T vs C: OR = 1.16, 95%CI = 1.12-1.20; TT vs CC: OR = 1.32, 95%CI = 1.24-1.41; TT vs CT+CC: OR = 1.15, 95%CI = 1.09-1.22; TT+CT vs CC: OR = 1.27, 95%CI = 1.21-1.34).
|
31008939 |
2019 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study provides summary evidence that variants in the PSCA gene are associated with risk of gastric and bladder cancer, gastritis, as well as duodenal and gastric ulcer and highlights the significant role of this gene in the pathogenesis of these diseases.
|
30407486 |
2019 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer.
|
28881685 |
2017 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three previously established bladder cancer risk-associated SNPs (rs798766 in TACC3, rs9642880 in MYC, and rs2294008 in PSCA) were genotyped in 1,210 bladder cancer patients and 1,008 control subjects in Shanghai, China.
|
24155119 |
2014 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
|
25117309 |
2014 |
Malignant neoplasm of urinary bladder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
PSCA is upregulated in prostate cancer, pancreatic cancer and bladder cancer, as well as a number of others, making it an ideal clinical target for both diagnosis and therapy.
|
24308679 |
2014 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.
|
25374226 |
2014 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, two of the UBC risk variants (PSCA and UGT1A) were confirmed to have functional consequences.
|
23752272 |
2013 |
Malignant neoplasm of urinary bladder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Future clinical studies will be needed to validate PSCA as a therapeutic target for bladder cancer.
|
23266392 |
2013 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Heterozymous and homozygous carriers of the SNP rs22940008 in the first exon of the PSCA gene are at increased risk for invasive bladder cancers.
|
23330817 |
2013 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors.
|
22416122 |
2012 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We constructed a bladder cancer-specific adenovirus carrying E1A-androgen receptor (AR) under the control of UPII promoter and prostate stem cell antigen enhancer (PSCAE), designated as Ad/PSCAE/UPII/E1A-AR, and investigated its antitumor effects in vitro and in vivo.
|
22218302 |
2012 |
Malignant neoplasm of urinary bladder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recent exciting findings that genetic variations of PSCA conferred increased risks of gastric cancer and bladder cancer have opened up a new avenue of research about the pathological function of PSCA.
|
20501618 |
2010 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |
Malignant neoplasm of urinary bladder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways.
|
20374648 |
2010 |
Malignant neoplasm of urinary bladder
|
0.500 |
Biomarker
|
disease |
CTD_human |
These results indicated that the rs2294008 polymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations.
|
20083643 |
2010 |
Malignant neoplasm of urinary bladder
|
0.500 |
Biomarker
|
disease |
BEFREE |
Prostate stem cell antigen enhancer and uroplakin II promoter based bladder cancer targeted tissue-specific vector.
|
18440837 |
2010 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that the rs2294008 polymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations.
|
20083643 |
2010 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations.
|
19648920 |
2009 |
Malignant neoplasm of urinary bladder
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations.
|
19648920 |
2009 |
Malignant neoplasm of urinary bladder
|
0.500 |
Biomarker
|
disease |
CTD_human |
A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations.
|
19648920 |
2009 |
Malignant neoplasm of urinary bladder
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data demonstrate that PSCA is overexpressed in a majority of human TCCs, particularly CIS and superficial tumors, and may be a useful target for bladder cancer diagnosis and therapy.
|
11406532 |
2001 |