BICC1, BicC family RNA binding protein 1, 80114

N. diseases: 52; N. variants: 14
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 AlteredExpression disease BEFREE Serum BICC1 levels in drug-free patients with MDD (n=30), BM (n=30), and BD (n=13), and well-matched healthy controls (HC, n=30) were measured with ELISA kits. 30697050 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 Biomarker disease BEFREE Bicaudal C homolog 1 gene (BICC1) in the medial prefrontal cortex (mPFC) has been implicated in major depressive disorder (MDD); however, less is known about the mechanisms of BICC1-induced depression. 31102751 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 GeneticVariation disease BEFREE Variants within three genes, BICC1, PCLO and GRM7 were selected for replication in our study based on the following criteria: they were identified in a prior MDD GWAS study; a subsequent study found evidence that they influenced depression risk; and there is a solid biological basis for a role in depression. 26391493 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 GeneticVariation disease BEFREE Intriguingly, we provide evidence that MDD associated polymorphisms alter the ability of the BICC1 promoter to respond to PKA signalling within amygdala neurones. 26440730 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 AlteredExpression disease BEFREE Here, we show that BICC1 mRNA is upregulated in the dorsolateral prefrontal cortex and dentate gyrus of human postmortem MDD patients. 25178406 2015
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 GeneticVariation disease GWASDB Dissecting the genetic heterogeneity of depression through age at onset. 22915352 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 GeneticVariation disease BEFREE These results are suggestive that the minor T-allele of BICC1 has a protective role against MDD and its known structural and functional brain changes. 22910460 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.160 GeneticVariation disease GWASDB Genome-wide association study of major recurrent depression in the U.K. population. 20516156 2010