|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin‑dependent kinase 5 regulatory subunit‑associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms.
|
30864700 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, low expression of CDK5RAP3 was correlated with more advanced TNM stage, increased tumor microvessel density, and poor prognosis.
|
31728130 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of CDK5RAP3 was closely related to the age of the patients (<i>P</i> = 0.035) and the T stage of the tumor (<i>P</i> = 0.017).
|
30228783 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
|
27793695 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, LZAP, a putative tumor suppressor, has been linked to dephosphorylation of several of these substrates, including RelA, p38, Chk1, and Chk2.
|
28027003 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we showed that in CDK5RAP3 stable knockdown SMMC-7721 HCC cells, p14(ARF) tumor suppressor was upregulated at protein and mRNA levels, and ectopic expression of CDK5RAP3 was found to repress the transcription of p14(ARF).
|
22860085 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A yeast two-hybrid screening identified that TIP-1, through its single PDZ domain, binds to the carboxyl terminus of LZAP that has been studied as one tumor suppressor functioning through ARF binding and p53 activation.
|
23028987 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LZAP has been highly conserved during evolution and has been shown to function as a tumor suppressor in various cancers.
|
22028922 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Injection of IC53 stably transfected HCT-116 cells into athymic nude mice promoted tumor growth.
|
21394385 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Computational analysis showed that IC53 cDNA is 2538 bp long, encoding 419 amino acids, mapped to chromosome 17q21.31 with 12 exons, ubiquitously expressed in 12 tested normal tissues and 8 tumor cell lines from MTN membranes and vascular endothelial cells by Northern blot and in situ hybridization, and upregulated in the rat models of subacute heart failure and chronic ischemic heart failure by left coronary ligation.
|
12054757 |
2002 |