|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This previously uncharacterized gene is fused with the tyrosine kinase (tk) domain of the RET proto-oncogene to generate the oncogenic sequence RET/PTC3, thus providing a third example of RET oncogenic activation in papillary thyroid carcinomas.
|
7529046 |
1994 |
|
Papillary thyroid carcinoma
|
0.400 |
FusionGene
|
disease |
ORPHANET |
Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.
|
8290261 |
1994 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.
|
8290261 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The karyotype of two RET/PTC3 positive tumors did not show any evidence of chromosome 10 abnormalities.
|
7529046 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally we provide evidence indicating that the rearrangement leading to the generation of RET/PTC3 occurred in vivo in the original tumor DNA.
|
8290261 |
1994 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we have successfully amplified the chimeric introns resulting from these inversions, ranging from 1.4 to 10 kb, from four of five tumors known to contain the ret/PTC-1 oncogene (where c-ret rearranges with the H4 gene), and from 1/1 tumors containing the ret/PTC-3 oncogene (where c-ret rearranges with the ele1 gene).
|
8634704 |
1995 |
|
Multiple Endocrine Neoplasia Type 2a
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To verify the role of RET in neuronal differentiation, we introduced into the human neuroblastoma cell line SK-N-BE four versions of the RET oncogene, activated by different mechanisms: RET/PTC1 and RET/PTC3, which are activated by rearrangement with heterologous genes; and two activated RET mutants, which carry the single amino acid substitution found associated to the inheritance of the multiple endocrine neoplasia type 2A (retMEN2A allele) and type2B (retMEN2B allele), respectively.
|
8562477 |
1995 |
|
Thyroid Neoplasm
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995).
|
8806700 |
1996 |
|
Thyroid carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995).
|
8806700 |
1996 |
|
Malignant neoplasm of thyroid
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995).
|
8806700 |
1996 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.
|
9192845 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, in all sporadic tumors and in one post-Chernobyl tumor the ELE1/RET recombination corresponded with short sequences of homology (3-7 nt) between the two rearranging genes.
|
9192845 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the types of ret/PTC vary between these two populations, with ret/PTC3 present more commonly in post-Chernobyl tumors.
|
9135009 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data concerning the radiation-associated tumors, showed that: (1) the overall frequency of ret rearrangements was 84% in papillary carcinomas (16/19) and 45% (9/20) in follicular adenomas; (2) in contrast with the results obtained in the Chernobyl tumors, the most frequently observed chimeric gene was RET/PTC1 instead of the RET/PTC3 and (3) all the tumors were negative for RET/PTC2.
|
9315093 |
1997 |
|
Carcinoma, Papillary
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our data concerning the radiation-associated tumors, showed that: (1) the overall frequency of ret rearrangements was 84% in papillary carcinomas (16/19) and 45% (9/20) in follicular adenomas; (2) in contrast with the results obtained in the Chernobyl tumors, the most frequently observed chimeric gene was RET/PTC1 instead of the RET/PTC3 and (3) all the tumors were negative for RET/PTC2.
|
9315093 |
1997 |
|
Carcinoma, Papillary
|
0.090 |
Biomarker
|
disease |
BEFREE |
The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful and specific markers of the early stages of papillary carcinoma as they are highly specific for malignant cells.
|
9001272 |
1997 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This result suggests a switch in the ratio of ret/PTC3 to ret/PTC1 rearrangements in late (1996) versus early (1991-1992) post-Chernobyl papillary thyroid cancers.
|
9848713 |
1998 |
|
Thyroid carcinoma
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5.
|
9443391 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We examined the expression of ret/PTC in 99 German papillary thyroid carcinomas, including two recently described new variants of ret/PTC3 and identified eight ret/PTC-positive tumours (8%) but none with the new variants.
|
9528832 |
1998 |
|
Carcinoma, Papillary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
One child with a solid variant papillary carcinoma had a ret-PTC3 rearrangement, further supporting the association between the solid variant histotype and this particular rearrangement of ret.
|
9669285 |
1998 |
|
Papillary thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan.
|
10083732 |
1999 |
|
Papillary thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present data suggest that ret/PTC3 may be typical for radiation-associated childhood PTC with a short latency period, whereas ret/PTC1 may be a marker for later-occurring PTC of radiation-exposed adults and children.
|
9935226 |
1999 |
|
Thyroid carcinoma
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
In three FAP patients, ret/PTC-1 and ret/PTC-3 were expressed in thyroid cancers.
|
9916927 |
1999 |
|
Thyroid carcinoma
|
0.370 |
Biomarker
|
disease |
BEFREE |
Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas.
|
10597232 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Surprisingly, the alignment of ELE1 and RET introns in opposite orientation revealed that in each tumor the position of the break in one gene corresponded to the position of the break in the other gene.
|
10597232 |
1999 |