|
Carcinoma, Papillary
|
0.090 |
Biomarker
|
disease |
BEFREE |
When the tumors were grouped further according to histologic subtypes, the prevalence of RET/PTC3 was greater in solid/solid-follicular papillary carcinomas than in classic papillary carcinomas.
|
16015630 |
2005 |
|
Carcinoma, Papillary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We and others have shown that RET-PTC3 rearrangements are associated with the solid morphology seen in these short latency tumours, while classical papillary carcinomas more often show RET-PTC1 rearrangements.
|
15150580 |
2004 |
|
Carcinoma, Papillary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
RET/PTC1 tends to be more common in tumors with typical papillary growth and microcarcinomas and to have a more benign clinical course, whereas RET/PTC3 in some populations shows a strong correlation with the solid variant of papillary carcinoma and more aggressive tumor behavior.
|
12114746 |
2002 |
|
Carcinoma, Papillary
|
0.090 |
Biomarker
|
disease |
BEFREE |
RET/PTC1 or RET/PTC3 were detected in microscopic foci with papillary carcinoma features in most of the thyroid nodules (five of seven cases).
|
12057919 |
2002 |
|
Carcinoma, Papillary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The two rearrangements resulting from inversion of part of chromosome 10 (PTC1 and PTC3) accounted for the majority of RET rearrangements identified, with PTC1 being associated with papillary carcinomas of the classic and diffuse sclerosing variants and PTC3 with the solid/follicular variant.
|
10646883 |
2000 |
|
Carcinoma, Papillary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
A strong correlation was observed between the solid-follicular subtype of papillary carcinoma and the RET/PTC3 isoform: 19 of the 24 RET/PTC-positive solid-follicular carcinomas harbored a RET/PTC3 rearrangement, whereas only 5 had a RET/PTC1 rearrangement.
|
10566678 |
1999 |
|
Carcinoma, Papillary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
One child with a solid variant papillary carcinoma had a ret-PTC3 rearrangement, further supporting the association between the solid variant histotype and this particular rearrangement of ret.
|
9669285 |
1998 |
|
Carcinoma, Papillary
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our data concerning the radiation-associated tumors, showed that: (1) the overall frequency of ret rearrangements was 84% in papillary carcinomas (16/19) and 45% (9/20) in follicular adenomas; (2) in contrast with the results obtained in the Chernobyl tumors, the most frequently observed chimeric gene was RET/PTC1 instead of the RET/PTC3 and (3) all the tumors were negative for RET/PTC2.
|
9315093 |
1997 |
|
Carcinoma, Papillary
|
0.090 |
Biomarker
|
disease |
BEFREE |
The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful and specific markers of the early stages of papillary carcinoma as they are highly specific for malignant cells.
|
9001272 |
1997 |