NCOA4, nuclear receptor coactivator 4, 8031

N. diseases: 62; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 AlteredExpression disease BEFREE Here, we firstly find CNTN1 is a new gene which can be regulated by RET/PTC3 (Ret proto-oncogene and Ret-activating protein ELE1) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer. 26722434 2015
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 Biomarker disease CTD_human Cancer-related genes transcriptionally induced by the fungicide penconazole. 23811263 2014
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 AlteredExpression disease BEFREE Three archival thyroid cancer tissue specimens from three different patients were used as in-house controls to determine the conditions for an improved switching mechanism at 5' end of RNA transcript (SMART) RACE method; one tissue specimen with RET/PTC1 rearrangement and one with RET/PTC3 rearrangement were used as positive samples. 19785523 2010
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 GeneticVariation disease BEFREE In this study, we use an 18 Mb region on 10q11.2-21 containing the RET gene and its recombination partners, the H4 and NCOA4 (ELE1) genes, as a model chromosomal region frequently involved in RET/PTC rearrangements in thyroid cancer. 16331264 2006
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 AlteredExpression disease BEFREE In three FAP patients, ret/PTC-1 and ret/PTC-3 were expressed in thyroid cancers. 9916927 1999
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 Biomarker disease BEFREE Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas. 10597232 1999
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 GeneticVariation disease BEFREE Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5. 9443391 1998
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.370 GeneticVariation disease BEFREE Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995). 8806700 1996