ADAM33, ADAM metallopeptidase domain 33, 80332

N. diseases: 49; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE In conclusion, ADAM33 has a key role in gastric cancer pathogenesis by up-regulating IL-18 secretion process, resulting in increased cell migration and proliferation. 19265133 2009
CUI: C1449563
Disease: Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Familial Idiopathic 		0.010 PosttranslationalModification disease BEFREE We suggest that ADAM33 promoter methylation may be a useful molecular marker for differentiating ILC and IDC. 19267929 2009
CUI: C0035455
Disease: Rhinitis
Rhinitis 		0.010 GeneticVariation disease BEFREE Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. 18778489 2008
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases 		0.010 Biomarker group BEFREE ADAM33 has been previously associated with asthma, which demonstrates that immune system diseases may be controlled by common susceptibility genes with general effects on dermal inflammation and immunity. 17878941 2007
CUI: C0847614
Disease: Nasal allergies
Nasal allergies 		0.010 GeneticVariation phenotype BEFREE However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy. 15298558 2004
CUI: C0043144
Disease: Wheezing
Wheezing 		0.020 GeneticVariation phenotype BEFREE Multiple associations were observed for ADAM33: rs2280090 was associated with reduced MEF240% (i.e., the ratio of Mean Expiratory Flow after 240s of hypertonic saline inhalation with respect to the age- and ancestry-matched reference value) and with an increased risk of allergic bronchitis (p = 1.77*10(-4) and p = 7.94*10(-4), respectively); rs3918396 was associated with wheezing and eczema comorbidity (p = 3.41*10(-4)). 27624002 2016
CUI: C0043144
Disease: Wheezing
Wheezing 		0.020 GeneticVariation phenotype BEFREE When replicated in the KOALA study, ADAM33 rs528557 showed a negative association of the CG/GG-genotype with progression of recurrent wheeze into childhood asthma (0.50 (0.26-0.97) p = 0.04) and no association with preschool wheeze. 25768087 2015
CUI: C0018621
Disease: Hay fever
Hay fever 		0.020 GeneticVariation disease BEFREE The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. 24751681 2014
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 Biomarker disease BEFREE The ADAM33 gene is associated with the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. 23861802 2013
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 Biomarker disease BEFREE The ADAM33 gene is associated with the pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. 23861802 2013
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.020 GeneticVariation disease BEFREE Moreover, we detected an association between ADAM33 genotype and the extent of atherosclerosis in a large cohort of coronary artery disease patients. 20227692 2010
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 GeneticVariation disease BEFREE Moreover, we detected an association between ADAM33 genotype and the extent of atherosclerosis in a large cohort of coronary artery disease patients. 20227692 2010
CUI: C0018621
Disease: Hay fever
Hay fever 		0.020 GeneticVariation disease BEFREE In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. 15298558 2004
CUI: C1827849
Disease: IgE-mediated allergic asthma
IgE-mediated allergic asthma 		0.030 GeneticVariation disease BEFREE To verify the association of transforming growth factor-beta1(TGF-beta1) (C-509T and T869C), CD14 (C-159T), IL-4 (C-590T), IL-4R (ILe50Val) and ADAM33 (S_2) gene polymorphisms with asthma severity in a sample of patients with mild, moderate and severe persistent atopic asthma. 18425216 2008
CUI: C1827849
Disease: IgE-mediated allergic asthma
IgE-mediated allergic asthma 		0.030 Biomarker disease BEFREE Twenty-three ADAM33 SNPs were genotyped by fluorescence correlation spectroscopy with the use of DNA from 155 families (538 members) identified through children with atopic asthma. 16650044 2006
CUI: C1827849
Disease: IgE-mediated allergic asthma
IgE-mediated allergic asthma 		0.030 GeneticVariation disease BEFREE However, our data may suggest a complex role of ADAM33 polymorphisms in asthma ethiology, especially in non atopic asthma. 16784537 2006
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.030 GeneticVariation phenotype BEFREE To assess whether genetic variants of ADAM33 are related to asthma in a Korean population, we conducted an association study of the ADAM33 gene with asthma susceptibility, bronchial hyper-reactivity and serum IgE in Korean asthmatics (n=326) and normal controls (n=151). 15196271 2004
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.030 Biomarker phenotype BEFREE The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. 15144468 2004
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.030 Biomarker phenotype BEFREE The ADAM33 gene has recently been associated with asthma and bronchial hyper-reactivity. 14720258 2004
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.060 Biomarker disease BEFREE The study evidences that silencing of ADAM33 can decrease the proliferation and increase the apoptosis of ASMCs in a rat model of allergic asthma, suggesting ADAM33 represents a potential investigative focus target aiding allergic asthma. 30450713 2018
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.060 GeneticVariation disease BEFREE Investigating the Association of ADAM33 Single Nucleotide Polymorphisms (SNPs) with Susceptibility to Allergic Asthma in Azerbaijan Population of Iran: A Case-control Study. 29149777 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.060 Biomarker disease BEFREE To study the association between ADAM33 and PS in the northeastern Chinese population. 24562625 2014
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.060 GeneticVariation disease BEFREE ADAM33 polymorphisms are associated with psoriasis in the northeastern Chinese Han population. 22269827 2011
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.060 GeneticVariation disease BEFREE Our data suggest that the ADAM33 gene may be associated with PS risk in the Chinese population. 20491578 2010
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.060 GeneticVariation disease BEFREE Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. 18923449 2009