|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ADAM33 (a disintegrin and metalloprotease domain-containing protein 33) gene, discovered through positional cloning, is the first to be associated with asthma and bronchial hyperresponsiveness.
|
21930123 |
2011 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
A disintegrin and metalloprotease 33 (ADAM33)/Adam33 is a susceptibility gene for asthma and bronchial hyperresponsiveness in human beings and mice.
|
19665773 |
2009 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To replicate the role of ADAM33 in childhood lung function and development of BHR and asthma.
|
19236319 |
2009 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A disintegrin and metalloprotease 33 (ADAM33) polymorphism is strongly associated with asthma and bronchial hyperresponsiveness.
|
18423563 |
2008 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
ADAM33, a disintegrin and metalloproteinase 33 gene, has been identified as a risk factor for asthma and bronchial hyperresponsiveness and has been postulated as a gene for airway remodeling.
|
17339047 |
2007 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
CTD_human |
ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population.
|
17061022 |
2007 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
ADAM33, the first asthma candidate gene identified by positional cloning, may be associated with childhood asthma, lung function decline and bronchial hyperresponsiveness.
|
16784537 |
2006 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent genetic studies have now provided evidence that ADAM33 may be involved in determining lung function throughout life, associated with early life lung function as well as increased decline therapeutic intervention in asthma and future work will focus on the mechanisms by which it alters lung function and bronchial hyperresponsiveness.
|
15953744 |
2006 |
|
Bronchial Hyperreactivity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It has been previously suggested that ADAM33, which is a member of a gene family that encodes membrane-anchored proteins with a disintegrin and a metalloprotease domain, is primarily expressed in lung fibroblasts and bronchial smooth muscle cells and has been associated with airway remodelling and bronchial hyperresponsiveness.
|
16893396 |
2006 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ADAM33 gene has recently been identified as being a potentially important asthma candidate gene, and polymorphisms in this gene have been shown to be associated with asthma and bronchial hyperresponsiveness in Caucasian individuals from several populations.
|
16773130 |
2006 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several ADAM33 protein isoforms occur in adult bronchial smooth muscle and in human embryonic bronchi and surrounding mesenchyme, strongly suggesting its importance in smooth muscle development and/or function, which could explain its genetic association with bronchial hyperresponsiveness.
|
15709049 |
2005 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variation in ADAM33 is strongly associated with asthma and bronchial hyperresponsiveness.
|
14742294 |
2004 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity.
|
15347848 |
2004 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target.
|
12885268 |
2003 |
|
Bronchial Hyperreactivity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The human Adam33 gene is located on chromosome 20p13, a region that has been linked to asthma and bronchial hyperresponsiveness.
|
12768445 |
2003 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
|
12110844 |
2002 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that metabolites of phthalate such as MEHHP, MECPP, MEOHP and Σ4MEHP may increase the intron 1 methylation level to elevate ADAM33 gene expression and have a protective effect on reducing the risk of breast cancer.
|
30226539 |
2018 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
CTD_human |
This study suggests that metabolites of phthalate such as MEHHP, MECPP, MEOHP and Σ4MEHP may increase the intron 1 methylation level to elevate ADAM33 gene expression and have a protective effect on reducing the risk of breast cancer.
|
30226539 |
2018 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
This study suggests that metabolites of phthalate such as MEHHP, MECPP, MEOHP and Σ4MEHP may increase the intron 1 methylation level to elevate ADAM33 gene expression and have a protective effect on reducing the risk of breast cancer.
|
30226539 |
2018 |
|
Breast Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that metabolites of phthalate such as MEHHP, MECPP, MEOHP and Σ4MEHP may increase the intron 1 methylation level to elevate ADAM33 gene expression and have a protective effect on reducing the risk of breast cancer.
|
30226539 |
2018 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
In the present study, we have produced monoclonal antibodies against the ADAM33 protein and have investigated the role of ADAM33 protein in breast cancer.
|
28294120 |
2017 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
In the present study, we have produced monoclonal antibodies against the ADAM33 protein and have investigated the role of ADAM33 protein in breast cancer.
|
28294120 |
2017 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
BEFREE |
In this study, we explored the involvement of ADAM33, another ADAM family member, in breast cancer.
|
19267929 |
2009 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
In this study, we explored the involvement of ADAM33, another ADAM family member, in breast cancer.
|
19267929 |
2009 |
|
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals.
|
30226539 |
2018 |