|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Of note, the PNPLA3 risk variant advances fibrosis in the total cohort as well as in the subgroups of patients with viral hepatitis and non-viral liver diseases and contributes 16% of the total cirrhosis risk.
|
21168459 |
2011 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.
|
21745286 |
2011 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the -1195GG genotype in COX-2 is a genetic marker for liver disease progression, while the PNPLA3 genotypes are not associated with disease progression in Japanese patients with chronic hepatitis C.
|
22863264 |
2012 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Aim of this study was to evaluate whether the I148M PNPLA3 polymorphism influences serum adiponectin in liver diseases and healthy controls.
|
22898488 |
2012 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
PNPLA3 148M is over-represented in ALD&NAFLD HCC patients, and is associated with occurrence at a less advanced stage of liver disease in ALD&NAFLD.
|
24155878 |
2013 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, the rs738409 rs738409" genes_norm="80339">I148M patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism has been demonstrated to influence steatosis susceptibility and fibrosis progression in patients with different liver diseases, but no data are yet available for CHB.
|
23564580 |
2013 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC.
|
23333103 |
2013 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study was conducted to determine whether PNPLA3 rs738409 SNPs affect development and prognosis of hepatocellular carcinoma (HCC) in patients with various liver diseases.
|
22869157 |
2013 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The G-allele in position rs738409 of patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with an increased hepatic concentration of triglyceride and is a risk factor for advanced liver disease.
|
23872669 |
2013 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The patatin-like phospholipase domain-containing 3 gene (PNPLA3) and the apolipoprotein C3 gene (APOC3) have been studied in relation to liver steatosis and liver disease outcome.
|
23808989 |
2013 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Several studies have reported an association between the genetic variant rs738409 (G) in the PNPLA3 gene and the risk of cirrhosis in various liver diseases.
|
23069476 |
2013 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we review the plethora of studies that unraveled the association between PNPLA3 and NAFLD in children and adults, discuss its distinct effects on liver and metabolic traits, and introduce the term PNPLA3-associated steatohepatitis (PASH) as a novel gene-based liver disease.
|
24222094 |
2013 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this mini-review, we summarize the current knowledge on (i) PNPLA3 variant(s) in the pathogenesis of liver diseases, and (ii) PNPLA3 gene regulation and potential function in liver.
|
22884299 |
2013 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, PNPLA3 is a key player in liver disease progression.
|
24222941 |
2013 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The objectives of this study were to determine the association between PNPLA3 and liver fibrosis severity, HCC risk, and HCC prognosis among patients with liver disease.
|
24445574 |
2014 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A variant (rs738409 C>G, encoding for rs738409" genes_norm="80339">p.I148M) in the PNPLA3 gene is associated with liver damage in chronic liver diseases.
|
24114809 |
2014 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This review describes the impact of genetic variants of interleukin 28B (IL28B; also known as interferon-lambda 3), inosine triphosphate pyrophosphatase (ITPA) and patatin-like phospholipase domain-containing 3 (PNPLA3) on therapeutic outcome and liver disease severity in HCV-infected patients.
|
26250055 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variation in both patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and the transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) influences severity of liver disease, and serum triglyceride concentrations in non-alcoholic fatty liver disease (NAFLD), but whether either genotype influences the responses to treatments is uncertain.
|
26272871 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variants of patatin-like phospholipase domain-containing 3 (PNPLA3) and diabetes are associated with liver disease severity, in patients with chronic hepatitis C (CHC) infection.
|
25457210 |
2015 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent advances include the identification of PNPLA3 as a modifier of disease outcome across the full spectrum of NAFLD from steatosis to advanced fibrosis and hepatocellular carcinoma; and the discovery of TM6SF2 as a potential "master regulator" of metabolic syndrome outcome, determining not only risk of advanced liver disease, but also cardiovascular disease outcomes.
|
26378644 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of PNPLA3 Polymorphism with Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases.
|
26745088 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The presence of a PNPLA3 risk allele had no independent impact on liver disease or virological response rates to PEGIFN/RBV therapy in our cohort of HIV/HCV coinfected patients.
|
26599080 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The human patatin-like phospholipase domain-containing-3 (PNPLA3) gene rs738409 C>G polymorphism is associated with several types of liver disease.
|
25378656 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous studies revealed that the common sequence variant I148M in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with liver fat content and liver diseases, but not with insulin resistance.
|
26439088 |
2015 |
|
Liver diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Adiponutrin (PNPLA3) variants may help to identify NAFLD patients at higher risk for liver disease progression towards advanced fibrosis and HCC.
|
26159280 |
2015 |