COL18A1, collagen type XVIII alpha 1 chain, 80781

N. diseases: 323; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0743323
Disease: Acute dyspnea
Acute dyspnea
0.010 Biomarker phenotype BEFREE Our main aim was to study the association between plasma endostatin and 90-day mortality in an unselected cohort of patients admitted to the ED for acute dyspnea. 31672650 2020
CUI: C1301700
Disease: Cardiovascular morbidity
Cardiovascular morbidity
0.010 AlteredExpression phenotype BEFREE Increased levels of circulating endostatin predicts cardiovascular morbidity and impaired kidney function in the general population. 31672650 2020
Congenital arteriovenous malformation
0.010 Biomarker disease BEFREE Thus, serial measurements of serum VEGF and endostatin after SRS might help predict RICs in patients with arteriovenous malformation treated by SRS. 30831282 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.010 AlteredExpression disease BEFREE Raised levels of serum endostatin might be associated with cardiovascular events in patients with stable coronary heart disease. 30959314 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.010 AlteredExpression disease BEFREE Raised levels of serum endostatin might be associated with cardiovascular events in patients with stable coronary heart disease. 30959314 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.010 Biomarker disease BEFREE Urinary chemokine C-X-C motif ligand 16 and endostatin as predictors of tubulointerstitial fibrosis in patients with advanced diabetic kidney disease. 31598726 2019
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.010 Biomarker disease BEFREE Endostatin and blood urea nitrogen (BUN) concentration were measured in mice with a glomerulonephritis phenotype. 31404120 2019
CUI: C0017921
Disease: Glycogen storage disease type II
Glycogen storage disease type II
0.010 AlteredExpression disease BEFREE AMD was an independent factor associated with lower levels of angiogenin (β = -0.29, <i>p</i> < 0.001), endostatin (β = -0.18, <i>p</i> < 0.001), FGF-basic (β = -0.18, <i>p</i> < 0.001), PlGF (β = -0.24, <i>p</i> < 0.001), miRNA-21-3p (β = -0.13, <i>p</i> = 0.01) and miRNA-155-5p (β = -0.16, <i>p</i> = 0.002); and with higher levels of FGF-acidic (β = 0.11, <i>p</i> = 0.03), miRNA-23a-3p (β = 0.17, <i>p</i> < 0.001), miRNA-126-5p (β = 0.13, <i>p</i> = 0.009), miRNA-16-5p (β = 0.40, <i>p</i> < 0.001), miRNA-17-3p (β = 0.13, <i>p</i> = 0.01), miRNA-17-5p (β = 0.17, <i>p</i> < 0.001), miRNA-223-3p (β = 0.15, <i>p</i> = 0.004), and miRNA-93 (β = 0.11, <i>p</i> = 0.04). 31731799 2019
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome
0.010 AlteredExpression disease BEFREE Mean H-scores for endostatin expression were higher in the active UC group than in the inactive UC and IBS groups, in the stroma and endothelium. 30892485 2019
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.010 Biomarker disease BEFREE To investigate serum levels of a panel of angiogenic inducers (VEGF, FGF-2, Angiopoietin 1, -2, soluble VCAM-1) and inhibitors (angiostatin, endostatin, pentraxin-3) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK), in order to gain further insights into the molecular mechanisms driving angiogenesis dysregulation in large-vessel vasculitis (LVV). 31573481 2019
CUI: C0039483
Disease: Giant Cell Arteritis
Giant Cell Arteritis
0.010 AlteredExpression disease BEFREE Anti-angiogenic factor (Angiostatin, Endostatin, PTX3) serum levels were significantly higher in both GCA and TAK patients compared to NC. 31573481 2019
CUI: C0041341
Disease: Tuberous Sclerosis
Tuberous Sclerosis
0.010 AlteredExpression disease BEFREE Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis. 30922357 2019
CUI: C0154916
Disease: Rubeosis iridis
Rubeosis iridis
0.010 Biomarker disease BEFREE UPARANT is an effective antiangiogenic agent in a mouse model of rubeosis iridis. 31243519 2019
CUI: C0206368
Disease: Exfoliation Syndrome
Exfoliation Syndrome
0.010 AlteredExpression disease BEFREE Evaluation of Aqueous Endocan and Endostatin Levels in Patients With Pseudoexfoliation Syndrome. 30339555 2019
CUI: C0278512
Disease: Metastatic osteosarcoma
Metastatic osteosarcoma
0.010 Biomarker disease BEFREE The addition of perioperative rh-endostatin to chemotherapy could significantly improve the DMFS and OS of patients with non-metastatic osteosarcoma. 31119057 2019
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma
0.010 Biomarker disease BEFREE Endostatin and Gal3BP may represent prognostic biomarkers for patients on ipilimumab treatment in metastatic melanoma and should be further evaluated. 30821848 2019
CUI: C0334533
Disease: Arteriovenous hemangioma
Arteriovenous hemangioma
0.010 Biomarker disease BEFREE Thus, serial measurements of serum VEGF and endostatin after SRS might help predict RICs in patients with arteriovenous malformation treated by SRS. 30831282 2019
CUI: C0340235
Disease: Bronchobiliary fistula
Bronchobiliary fistula
0.010 Biomarker phenotype BEFREE This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab. 31624752 2019
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive
0.010 Biomarker disease BEFREE This study aims to evaluate the influence of intermittent hypoxia (IH), a novel hallmark of OSA, on tumor and to access the anti-tumor effect of endostatin on a mouse model with OSA. 30293229 2019
CUI: C0751674
Disease: Lymphangioleiomyomatosis
Lymphangioleiomyomatosis
0.010 AlteredExpression disease BEFREE Endostatin levels were associated with DLCO and were higher in subjects with TSC-associated LAM compared to sporadic LAM. 30922357 2019
Arteriovenous Malformations, Cerebral
0.010 Biomarker group BEFREE Do Serum Vascular Endothelial Growth Factor and Endostatin Reflect Radiological Radiation-Induced Changes After Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations? 30831282 2019
CUI: C1266166
Disease: Intracortical osteosarcoma
Intracortical osteosarcoma
0.010 Biomarker disease BEFREE The aim of this study was to determine whether the addition of perioperative rh-endostatin to chemotherapy could improve the probability of distant metastasis-free survival (DMFS) and overall survival (OS) in patients newly diagnosed with non-metastatic conventional osteosarcoma. 31119057 2019
CUI: C1856184
Disease: HEMIHYPERPLASIA, ISOLATED
HEMIHYPERPLASIA, ISOLATED
0.010 Biomarker disease BEFREE Microvessel density (MVD) and vascular endothelial growth factor (VEGF) were determined for evaluating the anti-tumor effect of endostatin among the normoxia and IH conditions. 30293229 2019
CUI: C1969372
Disease: Tubulointerstitial fibrosis
Tubulointerstitial fibrosis
0.010 Biomarker phenotype BEFREE Urinary chemokine C-X-C motif ligand 16 and endostatin as predictors of tubulointerstitial fibrosis in patients with advanced diabetic kidney disease. 31598726 2019
Experimental Organism Basal Cell Carcinoma
0.010 Biomarker phenotype BEFREE Therefore, endostatin can inhibit the proliferation, invasion and EMT in BCC. 30720196 2019