Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High LAT1 expression in HCC was associated significantly with tumor size (P = 0.032), histological differentiation (P = 0.003), and tumor stage (P = 0.01).
|
23696029 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A genetically engineered mouse model of ATC was used to address the effect of blocking LAT1 on tumor growth in vivo.
|
30241549 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
L-type amino acid transporter 1 (LAT1) and CD98 are frequently expressed in various human cancers, and closely correlated with tumor aggressiveness and survival.
|
28052681 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This recycling process for basigin and CD98 promotes cell spreading and tumor growth in liver cancer xenografts.
|
26437640 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to study the distribution of two LAT1-targeting PET tracers, L-4-borono-2-<sup>18</sup>F-fluoro-phenylalanine (<sup>18</sup>F-FBPA) and L-3-<sup>18</sup>F-alpha-methyl tyrosine (<sup>18</sup>F-FAMT), in relation to the tumor blood flow, using rat xenograft models.
|
30820863 |
2019 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Prognosis tended to be worse in patients having tumors with LAT1-high/LAT2-low than LAT1-low/LAT2-high scores (P = 0.0686).
|
24890221 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LAT1 expression increases as cancers progress, leading to higher expression levels in high-grade tumors and metastases.
|
31376820 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Amino acid transporters are necessary for tumor growth, metastasis, and survival of various neoplasms; however, the clinicopathological significance of L-type amino acid transporter 1 (LAT1) and 4F2 cell surface antigen (4F2hc) in patients with pulmonary pleomorphic carcinoma (PPC) remainsunknown.
|
30300664 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of human LAT1 by small interfering RNAs resulted in marked in vitro cell-growth inhibition of human cancer cells, and in vivo tumor growth of HeLa cells in athymic mice was significantly inhibited by anti-human LAT1 mAb.
|
21371427 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LAT1 was the major influx transporter in tumor cell lines with 4000-fold higher expression than LAT2.
|
19447222 |
2009 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
L-type amino acid transporter 1 (LAT1) has an essential role in cell proliferation especially in neoplasms.
|
28370814 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of LAT1 was identified as an independent significant marker linked to worse prognosis in patients with CRC, and was correlated with tumor cell proliferation, tumor aggressiveness, and metastasis.
|
31092450 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).
|
29326164 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The gene expression level of L amino acid transport-system 1 (LAT1) was analyzed and correlated with tumor uptake of 123I-IMT.
|
21269932 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms.
|
21187458 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LAT1 protein was expressed in 15 out of 16 (93.75%) SDHx tumors, regardless of the <sup>18</sup>F-FDOPA positivity.
|
27900521 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate a requirement for CD98 in EC growth and suggest that CD98-specific reagents could have a dual anticancer effect: directly by inhibiting tumor cell proliferation and indirectly by preventing tumor angiogenesis.
|
27687603 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SLC7A5 mRNA and protein expression was significantly associated with the expression of the key regulator of tumour cell metabolism, c-MYC, specifically in luminal B tumours only (p = 0.001).
|
29566741 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mRNA expression levels of the amino acid transporters of system A (SLC38A1 and SLC38A2), system L (SLC7A5) and system ASC (SLC1A5) were higher in all eight tumors than in the normal lung, with widely varying expression patterns.
|
30334568 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased expression of LAT1 mRNA was associated with less differentiated tumors, local invasion, microscopic vascular invasion, and metastasis.
|
24168110 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The gene (SLC7A5) encoding system L amino-acid transporter 1 (LAT1) is overexpressed in murine lymphoma cells generated via T-cell deletion of the pten tumor suppressor, and also in human T-cell acute lymphoblastic leukemia (T-ALL)/lymphoma (T-LL) cells.
|
25482130 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The high expression of LAT1 protein was significantly associated with tumor differentiation, tumor depth (T factor), lymph node metastasis, venous invasion, recurrence, and clinical response.
|
29149426 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, CD98-transfected clones developed tumors in athymic mice.
|
10471392 |
1999 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The correlation between tumour uptake of (18)F-FAMT and L-type amino acid transporter 1 (LAT1) expression was determined.
|
23801167 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the role of the HAT 4F2hc/LAT1 in tumor growth and the application of LAT1 inhibitors and PET tracers for reduction of tumor progression and imaging of tumors are discussed.
|
23506863 |
2013 |