KDM5C, lysine demethylase 5C, 8242

N. diseases: 119; N. variants: 29
Disease: Single tumor ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1298180
Disease: Single tumor
Single tumor 		0.010 GeneticVariation phenotype BEFREE Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution. 22397650 2012