CAPN6, calpain 6, 827

N. diseases: 11; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.300 GeneticVariation disease UNIPROT
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. 30185659 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 Biomarker group BEFREE Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. 30185659 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Calpain 6 was less well known; however, it was recently identified to be involved in the carcinogenesis of certain types of malignant tumor. 28454386 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE However, the expression of calpain 6 may vary between distinct tumor stages of HNSCC. 28454386 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Further research demonstrated that miR-449a inhibited cancer cell proliferation and induced apoptosis via suppressing both POU2F1 and CAPN6. 26375440 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.030 AlteredExpression group BEFREE The study indicated that miR-449a functions as a tumor inhibitor in liver cancer by decreasing POU2F1 and CAPN6 expression in liver cancer. 26375440 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE Calpain-6 knockdown blocks tumor development in mouse and induces depletion of the cancer stem cell population. 30185659 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker group BEFREE Further research demonstrated that miR-449a inhibited cancer cell proliferation and induced apoptosis via suppressing both POU2F1 and CAPN6. 26375440 2016
CUI: C1261473
Disease: Sarcoma
Sarcoma
0.010 AlteredExpression group BEFREE Data from transcriptomic analyses reveal that calpain-6 expression in sarcomas inversely correlates with senescence markers. 30185659 2018
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue
0.010 AlteredExpression group BEFREE Data from transcriptomic analyses reveal that calpain-6 expression in sarcomas inversely correlates with senescence markers. 30185659 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 AlteredExpression phenotype BEFREE Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. 28454386 2017
Squamous cell carcinoma of the head and neck
0.010 Biomarker disease BEFREE Calpain 6 expression was analyzed using an HNSCC tissue microarray and these results were consistent with the statistical analysis of the bioinformatics data from the GEO, indicating that calpain 6 may be a tumor suppressor protein in HNSCC. 28454386 2017
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma
0.010 AlteredExpression disease BEFREE CAPN6 and POU2F1 protein and mRNA levels decreased in liver cancer cells with miR-449a overexpression using western blot and real time RT-PCR assays. miR-449a expression was lower in liver cancer tissues compared with their normal ones, so did the cells. 26375440 2016
Liver and Intrahepatic Biliary Tract Carcinoma
0.010 AlteredExpression disease BEFREE CAPN6 and POU2F1 protein and mRNA levels decreased in liver cancer cells with miR-449a overexpression using western blot and real time RT-PCR assays. miR-449a expression was lower in liver cancer tissues compared with their normal ones, so did the cells. 26375440 2016
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.010 AlteredExpression disease BEFREE CAPN6 and POU2F1 protein and mRNA levels decreased in liver cancer cells with miR-449a overexpression using western blot and real time RT-PCR assays. miR-449a expression was lower in liver cancer tissues compared with their normal ones, so did the cells. 26375440 2016