Azoospermia
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
In addition, some infrequent mutations have been identified in the ubiquitin-specific protease 9, Y-linked (USP9Y) and the synaptonemal complex protein 3 (SYCP3) gene that cause azoospermia.
|
16227348 |
2005 |
Azoospermia
|
0.140 |
Biomarker
|
disease |
BEFREE |
The association of this large deletion with normal fertility shows that USP9Y, hitherto considered a candidate gene for infertility and azoospermia, does not have a key role in male reproduction.
|
19246359 |
2009 |
Azoospermia
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
On the contrary, the phenotype of patients with deletion of both USP9Y and DBY seem to be invariably azoospermia with a testicular histology of Sertoli cell-only.
|
11097428 |
2000 |
Male infertility
|
0.140 |
GeneticVariation
|
phenotype |
BEFREE |
Deletions in these regions remove one or more of the candidate genes (DAZ, RBMY, USP9Y, and DBY) and cause severe testiculopathy leading to male infertility.
|
11294825 |
2001 |
Oligospermia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Deletions in the azoospermia factor region AZFa on the human Y chromosome and, more specifically, in the region that encompasses the ubiquitin-specific peptidase 9, Y-linked gene USP9Y have been implicated in infertility associated with oligospermia and azoospermia.
|
19246359 |
2009 |
Oligospermia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
While deletions or even smaller mutations in USP9Y seem to be associated with a testicular phenotype of severe hypospermatogenesis, patients with deletions of DBY may present both Sertoli cell-only syndrome and severe hypospermatogenesis.
|
11097428 |
2000 |
Oligospermia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
One of these two patients had DFFRY deletion and the other had DBY deletion; their testicular phenotypes were Sertoli cell-only syndrome and hypospermatogenesis, respectively.
|
11695273 |
2001 |
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
USP9Y-TTTY15 expression is neither higher in cancer than adjacent normal tissues, nor correlated with features of advanced prostate cancer.
|
25188740 |
2014 |
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Real-time quantitative polymerase chain reaction was performed to evaluate the expression of TTTY15-USP9Y and the prostate cancer-specific antigen (PSA) level.
|
26008593 |
2015 |
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Real-time quantitative polymerase chain reaction was performed to evaluate the expression of TTTY15-USP9Y and the prostate cancer-specific antigen (PSA) level.
|
26008593 |
2015 |
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
USP9Y-TTTY15 expression is neither higher in cancer than adjacent normal tissues, nor correlated with features of advanced prostate cancer.
|
25188740 |
2014 |
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
USP9Y-TTTY15 expression is neither higher in cancer than adjacent normal tissues, nor correlated with features of advanced prostate cancer.
|
25188740 |
2014 |
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TBL1Y(A) USP9Y(A) haplotype of the Y chromosome, present only in black people of African origin, attributes a favorable lipoprotein pattern, likely to contribute to their reduced susceptibility to coronary heart disease.
|
18511697 |
2008 |
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TBL1Y(A) USP9Y(A) haplotype of the Y chromosome, present only in black people of African origin, attributes a favorable lipoprotein pattern, likely to contribute to their reduced susceptibility to coronary heart disease.
|
18511697 |
2008 |
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DFFRY-derived peptide was recognized by an HLA-A1 restricted CTL clone, generated during graft rejection from a female patient with acute myeloid leukemia who rejected HLA-phenotypically identical bone marrow from her father.
|
10648428 |
2000 |
Multiple Myeloma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate lineage-specific chimerism of plasma cells after allogeneic transplantation by real-time PCR based on bi-allelic sequence polymorphism or, in case of female-to-male transplantation, on the detection of the DFFRY gene and to determine its value to quantify minimal residual disease in myeloma patients.
|
16647575 |
2006 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We tested transcripts of 14 Y chromosomal genes by RT-PCR (TSPY, DAZ, BPY1 and BPY2, PRY, XKRY, CDY1 and CDY2, TTY1 and TTY2, PRKY, RBMY1, DBY and USP9Y), and only transcript of TSPY was detectable in the tumor tissue.
|
16784771 |
2006 |
Neoplasm, Residual
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To investigate lineage-specific chimerism of plasma cells after allogeneic transplantation by real-time PCR based on bi-allelic sequence polymorphism or, in case of female-to-male transplantation, on the detection of the DFFRY gene and to determine its value to quantify minimal residual disease in myeloma patients.
|
16647575 |
2006 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
USP9Y-TTTY15 expression is neither higher in cancer than adjacent normal tissues, nor correlated with features of advanced prostate cancer.
|
25188740 |
2014 |
Congenital absence of germinal epithelium of testes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
One of these two patients had DFFRY deletion and the other had DBY deletion; their testicular phenotypes were Sertoli cell-only syndrome and hypospermatogenesis, respectively.
|
11695273 |
2001 |
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TBL1Y(A) USP9Y(A) haplotype of the Y chromosome, present only in black people of African origin, attributes a favorable lipoprotein pattern, likely to contribute to their reduced susceptibility to coronary heart disease.
|
18511697 |
2008 |
Spermatogenic Failure, Nonobstructive, Y-Linked
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Azoospermia
|
0.140 |
GeneticVariation
|
disease |
LHGDN |
Study of azoospermia factor-a deletion caused by homologous recombination between the human endogenous retroviral elements and population-specific alleles in Japanese infertile males.
|
17624343 |
2008 |
Male infertility
|
0.140 |
Biomarker
|
phenotype |
LHGDN |
[A genetic study on microdeletion of azoospermia factor region on Y chromosome of azoospermia and oligozoospermia patients].
|
15696490 |
2005 |
Male infertility
|
0.140 |
GeneticVariation
|
phenotype |
LHGDN |
SRY and AZF gene variation in male infertility: a cytogenetic and molecular approach.
|
17762975 |
2007 |