|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
BEFREE |
NUP98-HOXD13 (NHD13) and CALM-AF10 (CA10) are oncogenic fusion proteins produced by recurrent chromosomal translocations in patients with acute myeloid leukemia (AML).
|
22885519 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
BEFREE |
In summary, this study indicates that collaboration of the clathrin-binding and the OM-LZ domains of CALM-AF10 is sufficient to induce AML.
|
21681188 |
2011 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
A 27-year-old woman was diagnosed with AML with the PICALM-MLLT10 fusion gene.
|
20875875 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
This case fits with and extends a recently proposed multistage AML model in which constitutive activation of tyrosine kinases by mutations (BCR-ABL1) are associated with deregulation of transcription factors central to myeloid differentiation (HOXA9 secondary to PICALM-MLLT10).
|
16518848 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
GeneticVariation
|
disease |
LHGDN |
As in the murine model, human CALM/AF10-positive AML was characterized by CD45RA (B220)-positive, IG DH-JH rearranged leukemic cells.
|
17097559 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The Clathrin Assembly Lymphoid Myeloid leukemia gene (CALM or PICALM) was first identified as the fusion partner of AF10 in the t(10;11)(p13;q14) translocation, which is observed in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and malignant lymphoma.
|
16491119 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
LHGDN |
A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.
|
12461747 |
2003 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In this study we analyzed the CALM/AF10 and AF10/CALM fusion mRNAs in a series of three patients with AML, one patient with T-ALL and two patients with precusor T lymphoblastic lymphoma.
|
10637482 |
2000 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
BEFREE |
Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia.
|
10637483 |
2000 |
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Leukemia, Myelocytic, Acute
|
0.490 |
Biomarker
|
disease |
HPO |
|
|
|