|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, an increased co-localization of E-CADHERIN and VIMENTIN, an increased number of cells expressing WNT2b and a higher expression of FZD4 and WNT2b/FZD4 interaction were detected in intestinal tissue from the penetrating compared with the stenotic CD behavior.
|
31359032 |
2020 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chemerin receptor (CMKLR1) is a G protein-coupled receptor (GPCR) implicated in macrophage-mediated inflammation and in several forms of human arthritis.
|
30576947 |
2019 |
|
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Protease-activated receptor 1 (PAR1), a thrombin-responsive G protein-coupled receptor (GPCR), is implicated in promoting metastasis in multiple tumor types, including both sarcomas and carcinomas, but the molecular mechanisms responsible remain largely unknown.
|
31420608 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer.
|
31289610 |
2019 |
|
Merkel cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied the expression of pH-GPCRs in selected skin cancers, that is Merkel cell carcinoma (MCC), dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS).
|
30339292 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases.
|
31132237 |
2019 |
|
Decompression Sickness
|
0.010 |
Biomarker
|
disease |
BEFREE |
Findings include: (i) The activation of one member of the Frizzled receptors (FZD4) involves a bending of transmembrane helix TM7 far larger than that in class A GPCRs.
|
30933747 |
2019 |
|
Diarrhea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Glaucoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The orphan G-protein-coupled receptor (GPCR) GPR158 is expressed in the brain, where it is involved in the osteocalcin effect on cognitive processes, and at the periphery, where it may contribute to glaucoma and cancers.
|
31189666 |
2019 |
|
Heartburn
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions.
|
30696114 |
2019 |
|
Hunger
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The cannabinoid receptor type 1 (CB1R), a G protein-coupled receptor (GPCR), plays an essential role in the control of many physiological processes such as hunger, memory loss, gastrointestinal activity, catalepsy, fear, depression, and chronic pain.
|
31771126 |
2019 |
|
Disruptive, Impulse Control, and Conduct Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Since 5-HT2CR is a class A G protein-coupled receptor (GPCR), drug discovery efforts have traditionally pursued the activation of the receptor through synthetic ligands with agonists proposed for the treatment of obesity, substance use disorders and impulse control disorders while antagonists may add value for the treatment of anxiety, depression and schizophrenia.
|
31288724 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor type 5 (mGluR<sub>5</sub>), a prototypical class C G protein-coupled receptor (GPCR), have shown therapeutic potential for various neurological disorders.
|
31025859 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPR18, a G protein-coupled receptor (GPCR), is involved in bacterial clearance and survival in microbial sepsis.
|
30503722 |
2019 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
(c) For any other combination of GPCR and skin disease, we found positive/negative mixed results.
|
30339292 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer.
|
31289610 |
2019 |
|
Cataract
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cataract surgery may improve the visual acuity of the eyes with congenital macular coloboma and cataract at some degree, and heterozygous mutations of FZD4 and NOD2 may be involved in the occurrence of congenital macular coloboma and cataract.
|
30882657 |
2019 |
|
Papillary thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Whole exome sequencing (WES) recently identified frequent mutations in the genes of GPCR-mediated PI3K pathway (<i>LPAR4</i>, <i>PIK3CA</i>, and <i>PTEN</i>) in a Chinese population with papillary thyroid cancers (PTCs).
|
31289610 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPR18, a G protein-coupled receptor (GPCR), is involved in bacterial clearance and survival in microbial sepsis.
|
30503722 |
2019 |
|
Cardiovascular Abnormalities
|
0.010 |
AlteredExpression
|
group |
BEFREE |
An over activation of GPCR mediated Gαq dependent signalling pathway is widely associated with the development of cardiovascular abnormalities.
|
31330058 |
2019 |
|
Mixed anxiety and depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Since 5-HT2CR is a class A G protein-coupled receptor (GPCR), drug discovery efforts have traditionally pursued the activation of the receptor through synthetic ligands with agonists proposed for the treatment of obesity, substance use disorders and impulse control disorders while antagonists may add value for the treatment of anxiety, depression and schizophrenia.
|
31288724 |
2019 |
|
Vascular calcification
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Si-WNT8b reduced the levels of WNT8b, frizzled-4, β-catenin, phospho-GSK-3β (p-GSK-3β), and cyclin-D, whereas it increased the levels of p-β-catenin and GSK-3β, indicating that si-WNT8b could alter the Wnt-β-catenin signaling pathway and thus hamper the VC in T/G HA-VSMC, which was further demonstrated by the TOP/FOP-Flash assay and detection of the β-catenin expression level in the nucleus.
|
30461014 |
2019 |
|
Ocular albinism, type I
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ocular albinism type 1 (OA1), a pigment cell-specific integral membrane glycoprotein, is a member of the G-protein-coupled receptor (GPCR) superfamily that binds to heterotrimeric G proteins in mammalian cells.
|
31275171 |
2019 |
|
Dermatofibrosarcoma Protuberans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied the expression of pH-GPCRs in selected skin cancers, that is Merkel cell carcinoma (MCC), dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS).
|
30339292 |
2019 |