|
Acromegaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of the p16 protein was lower than in the NFA group than in the CD and acromegaly groups (p = 0.030, p = 0.033, respectively), and E2F1 protein expression was significantly higher in the NFA group than in the CD group (p = 0.025). p73 protein expression in patients with acromegaly was significantly higher (p = 0.031) than that in the CD group.
|
31828584 |
2020 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Silencing of p73 in acute leukemia and in Burkitt's lymphoma occurs in association with the aberrant methylation of the first exon of the gene.
|
11002429 |
2000 |
|
Acute lymphocytic leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that p73 inactivation may be involved in the pathogenesis of both T- and B-ALLs, and that hypermethylation is the predominant mechanism of inactivation of the p73 gene in ALL.
|
11337015 |
2001 |
|
Acute lymphocytic leukemia
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
In both leukemia cell lines and primary ALLs, methylation was associated with transcriptional loss of p73 by reverse transcription-PCR.
|
10416592 |
1999 |
|
Acute lymphocytic leukemia
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
This study suggested rs1966862 (ARHGAP24) and the other SNPs to be predictive factors for drug-induced hepatotoxicity during the maintenance phase in pediatric patients with ALL or LBL.
|
20670164 |
2010 |
|
Acute lymphocytic leukemia
|
0.080 |
Biomarker
|
disease |
BEFREE |
Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.
|
20807569 |
2011 |
|
Acute lymphocytic leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of p73 was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in cell lines (5 of 7 pre B/B-acute lymphoblastic leukemia [ALL], 13 of 21 T-ALL/lymphoblastic lymphomas [LBL], 9 of 10 B-non-Hodgkin's lymphomas [B-NHL], 8 of 9 acute myelogenous leukemias [AML], 2 of 2 T-NHL, 3 of 3 multiple myeloma), and in patient samples (16 of 23 pre B-ALL, 5 of 8 T-ALL/LBL, 5 of 8 B-NHL).
|
10419905 |
1999 |
|
Acute lymphocytic leukemia
|
0.080 |
PosttranslationalModification
|
disease |
BEFREE |
Assessment of P73 methylation may provide important prognostic information, as was confirmed in patients with ALL.
|
16541141 |
2006 |
|
Acute lymphocytic leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia.
|
16791269 |
2006 |
|
Acute lymphocytic leukemia
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Expression level of p73 m RNA was also examined in 40 ALL samples using reverse transcriptase/polymerase chain reaction.
|
15649410 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, the distinct gene expression profile of p73 further supports the notion that acute promyelocytic leukemia is a biologically different subset of AML.
|
15385938 |
2004 |
|
Adenocarcinoma
|
0.040 |
GeneticVariation
|
group |
BEFREE |
A glutamine to arginine mutation was detected in exon 5 of the p73 gene in a case of adenocarcinoma at the gastro-oesophageal junction.
|
12560466 |
2003 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that p73 and DeltaNp73 are frequently overexpressed in >60% of primary adenocarcinomas of the stomach and esophagus.
|
15374945 |
2004 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings strongly suggest that p73 is not the target of 1p36 LOH in ovarian adenocarcinomas but indicate the presence of an, as yet unidentified, tumour suppressor gene in this region that plays an important role in ovarian tumorigenesis.
|
10467409 |
1999 |
|
Adenocarcinoma
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype.
|
10471526 |
1999 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares some p53-like activity, but in addition, may also play a role in gastrointestinal epithelial inflammatory responses.
|
11720435 |
2001 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Colorectal adenocarcinoma that expressed p73 showed significantly greater vascularity than p73-negative tumors (P = 0.012).
|
12865464 |
2003 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In human lung adenocarcinomas we identified a correlation between serine biosynthetic pathway and p73 expression.
|
24186203 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our data in vitro suggest that p73 G4C14-A4T14 polymorphism has no significant relationship to the cisplatin-based chemosensitivity in human lung adenocarcinoma.
|
19947923 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Benzo(a)pyrene induces p73 mRNA expression and necrosis in human lung adenocarcinoma H1299 cells.
|
20862736 |
2012 |
|
Adenoma
|
0.030 |
Biomarker
|
group |
BEFREE |
Allelic loss of p73 was identified in four adenomas (25%, 4/16 informative cases) that were all from the group of the nine adenomas with LOH, but somatic mutation was not detected in the remaining allele.
|
11301342 |
2001 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Promoter hypermethylation of the RB1, p14(ARF), p15(INK4b), p16(INK4a), p21(Waf1/Cip1), p27(Kip1), and p73 genes was detected in 12 (35%), 2 (6%), 11 (32%), 20 (59%), 1 (3%), 0 (0%), and 4 (12%) of the adenomas, respectively.
|
17216555 |
2007 |
|
Adenoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
In summary, epithelial ovarian cancers express a more complex p73 isoform pattern and higher levels of p73 mRNA and protein than ovarian adenomas.
|
10962441 |
2000 |
|
Adult Acute Lymphocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Expression level of p73 m RNA was also examined in 40 ALL samples using reverse transcriptase/polymerase chain reaction.
|
15649410 |
2005 |
|
Adult Acute Lymphocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of p73 was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in cell lines (5 of 7 pre B/B-acute lymphoblastic leukemia [ALL], 13 of 21 T-ALL/lymphoblastic lymphomas [LBL], 9 of 10 B-non-Hodgkin's lymphomas [B-NHL], 8 of 9 acute myelogenous leukemias [AML], 2 of 2 T-NHL, 3 of 3 multiple myeloma), and in patient samples (16 of 23 pre B-ALL, 5 of 8 T-ALL/LBL, 5 of 8 B-NHL).
|
10419905 |
1999 |