|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tau truncated by caspase-3 (D421) or tau hyperphosphorylated at Ser396/S404 might play a role in the pathogenesis of AD.
|
28084594 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Therapeutic
|
disease |
RGD |
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease.
|
29777699 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Therapeutic
|
disease |
RGD |
Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model.
|
29587274 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In summary, we identified the anti-apoptotic role of let-7f-5p in Aβ<sub>25-35</sub>-induced cytotoxicity, as well as the protective effect of let-7f-5p on survival of grafted MSCs by targeting caspase-3 in AD models.
|
29872375 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Therapeutic
|
disease |
RGD |
Effects of Lignans from Schisandra chinensis Rattan Stems against Aβ
|
29642617 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Caspase-3 and GSK-3β inhibitor ameliorated memory impairments and synaptic deficits in Aβ-injected AD model mice.
|
29079294 |
2018 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of B cell lymphoma 2 (Bcl‑2) were increased, and the expression levels of caspase‑3, Bcl‑2 associated X protein and AD‑associated proteins were decreased in the hippocampus following treatment with vildagliptin.
|
29257340 |
2018 |
|
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, reconstitution of Sca-1 KO mice with WT Sca-1<sup>+</sup> cells was associated with the reactivation of EMT and improved cardiac function after MI.
|
29556355 |
2018 |
|
Myocardial Infarction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Caspase-3 activity was higher in the amygdala (medial and lateral) and hippocampal CA3 region in untreated MI rats, whereas caspase-6 activity was higher in the CA1 region.
|
30486235 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, Hippocampal neuron apoptosis was induced by diabetes + SAH and expression levels of caspase-3, Bax and Bcl-2 were also increased.
|
29399092 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
Biomarker
|
disease |
BEFREE |
Meanwhile, the combination therapy attenuates apoptosis as shown by an increased Bcl-2 expression, decreased Bax expression and release of cytochrome c, and reduction of cleaved caspase-9 and caspase-3 at 24h after SAH.
|
29258835 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our data show that early treatment with atorvastatin effectively ameliorates EBI after SAH through anti-apoptotic effects and the effects might be associated inhibition of caspase-3 and endoplasmic reticulum (ER) stress related proteins CHOP and GRP78.
|
29592873 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increased levels of SOD2, Bax, and cleaved caspase-3 following SAH were reduced in the SAH + melatonin-treated group; reduced levels of Sirt3 and Bcl-2 following SAH were increased in the SAH + melatonin-treated group.
|
29872034 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Treatment with the p53 inhibitor, pifithrin‑α, suppressed p53 protein expression, increased IL‑6 mRNA expression, decreased microRNA‑22 expression, Bax protein expression and caspase‑3 activity, and induced Cyr61 expression in mice with SAH.
|
29336471 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
Biomarker
|
disease |
BEFREE |
This finding was associated with an observed decrease in Bax/Bcl-2 ratio, cytochrome-c and PUMA expression, and the suppression of caspase-3 activation following SAH.
|
30036663 |
2018 |
|
Subarachnoid Hemorrhage
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Levels of caspase-3, bax and bcl-2, all showed a temporary rise after SAH in the hypothalamus, indicating the induction of apoptosis in this brain region.
|
29497296 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sepsis acutely increased apoptosis (increased caspase-3 and PARP cleavage), autophagosome formation (increased LC3B-II), and canonical inflammasome activity (increased NLRP3, TMS1, cleaved caspase-1).
|
29240643 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis.
|
29756489 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The effect may be mediated by up-regulation of survivin via activation of NF-κB, which leads to reduced activation of caspase-3 and consequent apoptosis of cardiomyocytes in experimental sepsis.
|
30279549 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Following sepsis induction, diagnosis, the brains were analyzed for both function and ultrastructural morphology.We determined that IAH exacerbated sepsis induces sepsis-associated encephalopathy when examining low score of neurological function and more delta wave in EEG, increased neuronal edema in LPS + IAH group, as well as an escalation of Bax and Cleaved-caspase-3, Cleaved-parp, and reduction of Bcl-2 and Mfsd2a in LPS + IAH group.
|
29802336 |
2018 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Extracts were also tested in cell free assays as inhibitors of caspase-1 and matrix metalloproteinase-3 (enzymes associated with inflammation) and caspase-3, which has been shown to cleave protein Tau, an early event in the development of Alzheimer's disease.
|
27473605 |
2017 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Aβ<sub>1-42</sub> mice that received E2 treatment during the early stage of AD pathology exhibited significant reductions in the production of nitric oxide (NO) and reactive oxygen species (ROS), a marked decrease in the activation of Cytochrome-c/Bax/Bcl-2/caspase-3 pathway, a notable decrease in the level of gliosis a significant increase in the number of synapses (ultrastructural investigation), and a marked upregulation in synaptic function-related proteins compared to mice that received E2 treatment during the late stage of AD pathology.
|
27838872 |
2017 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to their role in amyloid processing, caspase-8 and its downstream effector caspase-3 are involved in synaptic plasticity, learning, memory and control of microglia pro-inflammatory activation and associated neurotoxicity, indicating additional mechanisms that might contribute to AD.
|
28985224 |
2017 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this work, the effect of M2000 on the treatment of Alzheimer's disease (AD) was performed by Morris water maze experiment, and the immunological assessments were carried out by Western blot, apoptosis (procaspase-3, Bax/Bcl<sub>2</sub>, P53), enzymatic (superoxide dismutase [SOD]), and nonenzymatic oxidative stress (malondialdehyde [MDA]) tests.
|
28100077 |
2017 |
|
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
So we became interested to examine in vitro the effect of phospho-Ser<sup>422</sup> residue on hTau cleavage by caspase-3 which is a crucial upstream event associated with hTau self-assembly leading to AD pathogenesis.
|
27989667 |
2017 |