|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer's Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [<sup>68</sup>Ga]Ga-TC3-OGDOTA.
|
30755766 |
2019 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Catalpol increased the number of newborn immature neurons, as determined by BrdU<sup>+</sup>-Nestin<sup>+</sup> and BrdU<sup>+</sup>-Tuj-1<sup>+</sup> staining, and downregulated cleaved caspase 3 in Tuj-1<sup>+</sup> cells at day 7 following stroke.
|
31849446 |
2019 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Our findings suggested that three times or more per week of high-intensity preconditioning exercise exert neuroprotective effects through the downregulation of the Bax/Bcl-2 ratio and caspase-3 activation after stroke.
|
30822224 |
2019 |
|
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
We asked whether the potential neuroprotection of PNS-Rb1 on the brain is due to, at least partially, its modulation of AkT/mTOR/PTEN signalling pathway along with down-regulation of caspase-3 in rats subjected to phototrombic stroke.
|
29501622 |
2018 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Furthermore, iASPPi downregulated iASPP expression, and upregulated the expression of proapoptotic effectors, Puma, Bax and cleaved caspase-3, in mice after stroke treated with mild therapeutic hypothermia.
|
29896428 |
2018 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Furthermore, caspase-1 inhibitors for contact dermatitis and inflammation, cardiovascular diseases, and liver diseases and a caspase-3 inhibitor for cerebral stroke have been patented.
|
28885866 |
2018 |
|
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation.
|
29278729 |
2018 |
|
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
However, the expression of cleaved caspase-3 was significantly attenuated after treatment of stroke with P2X7R antagonist (BBG) or NLRP3 inhibitor (MCC950).
|
28274860 |
2017 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The results showed that the expressions of LC3-II and cleaved caspase-3 were gradually increased from 1 to 5 hours, and reached maximum at 5 hours after stroke.
|
28506087 |
2017 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Collectively, these studies show that mir363 is neuroprotective for stroke in females and implicates caspase-3 as a sex-specific miRNA-sensitive node for recovery from ischemic stroke.
|
27773791 |
2017 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Disruption of the MIF gene in MIF-knockout mice resulted in caspase-3 activation, neuronal loss, and increased infarct development during stroke in vivo.
|
24970391 |
2014 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Here, we show that cleaved caspase-3 was increased in newborn neuronal precursor cells (NPCs) in the subventricular zone (SVZ) and the dentate gyrus during the period of stroke recovery, with no evidence of apoptosis.
|
23939807 |
2014 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Intravenous human umbilical cord blood transplantation for stroke: impact on infarct volume and caspase-3-dependent cell death in spontaneously hypertensive rats.
|
21087606 |
2011 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
RGD |
In conclusion, beta-catenin degraded after stroke, and its degradation was caspase-3 dependent.
|
18463494 |
2008 |
|
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
The main neuroprotective mechanisms of VEGF include: (1) modulation of the phosphatidylinositol 3'-kinase (PI3K)/Akt/nuclear factor-kappaB signaling pathway, inhibition of caspase-3 activity, and reduction of ischemic neuronal apoptosis; (2) inhibition of outward delayed rectifier potassium channel currents and increase of ischemia-induced tyrosine phosphorylation of Kv1.2 potassium channel proteins via activation of the PI3K pathway; and (3) enhancement of proliferation and migration of neural progenitors in the subventricular zone and improvement of striatal neurogenesis and maturation of newborn neurons in adult rat brains after stroke.
|
15573409 |
2005 |