CASP3, caspase 3, 836

N. diseases: 819; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE In addition, PER administration also decreased the lung tissue NF-κB and Caspase-3 immunopositivity against sepsis. 31733315 2020
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Western blot and quantitative real time-polymerase chain reaction (qRT-PCR) were conducted to detect the protein and mRNA expression levels of LC3, Beclin-1, activated caspase-3, p-Akt (308), p-Akt (472), Akt and NKILA in kidney tissues of sepsis rats at different time points, respectively. 31599426 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The expression of α7nAChR, toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1), and cleaved caspase-3 increased, peaking 24 h during sepsis. 31520992 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Sepsis acutely increased apoptosis (increased caspase-3 and PARP cleavage), autophagosome formation (increased LC3B-II), and canonical inflammasome activity (increased NLRP3, TMS1, cleaved caspase-1). 29240643 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis. 29756489 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE The effect may be mediated by up-regulation of survivin via activation of NF-κB, which leads to reduced activation of caspase-3 and consequent apoptosis of cardiomyocytes in experimental sepsis. 30279549 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Following sepsis induction, diagnosis, the brains were analyzed for both function and ultrastructural morphology.We determined that IAH exacerbated sepsis induces sepsis-associated encephalopathy when examining low score of neurological function and more delta wave in EEG, increased neuronal edema in LPS + IAH group, as well as an escalation of Bax and Cleaved-caspase-3, Cleaved-parp, and reduction of Bcl-2 and Mfsd2a in LPS + IAH group. 29802336 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Therapeutic disease RGD Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. 29180187 2017
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The percentage of the immunostained positive area in the spiral ligament significantly correlated with the grade of hearing loss for BAX (<i>P</i>=0.027) and Cleaved-caspase 3 (<i>P</i>=0.024) but not for BCL 2 (<i>P</i>>0.05).The present data suggests that severe, non-lethal sepsis in mice results in significantly elevated hearing thresholds. 28404559 2017
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Besides, we detected the increasing expression level of Caspase-3 and increasing ratio of TUNEL positive cells in the thyroid after sepsis. 27521250 2016
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE In this study, we investigated the prognostic value of cfDNA in patients with sepsis and its possible correlation with caspase-3, IL-6 and IL-18 levels. 26960212 2016
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065 2005