Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CCK-8, EdU, transwell, western blot and caspase-3 activity analyses were utilized to testify the role of LINC00467 in HCC.
|
31656043 |
2020 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Chrysin was able to increase caspase-3 activity in the HCC rats group (about 2.4 fold) compared to the normal rats group.
|
31708277 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition to melanoma, the DGKα inhibitors enhanced caspase 3/7 activity and reduced the viability of hepatocellular carcinoma, glioblastoma, and pancreatic cancer cells, but not breast adenocarcinoma cells.
|
30536880 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2.
|
30725182 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
SCL2A9 induced HCC cell apoptosis by inhibiting the expression of caspase 3.
|
29523220 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The result confirmed that the HCC condition was developed in response to lower expressions of caspase 3 and 9 which, in turn, was due to the upstream regulation of iNOS, Bcl-xl and Bcl-2, and downstream regulation of eNOS, BAX, BAD and Cyt C. The treatment with ZOL caused the significant activation of caspase mediated apoptotic signals that could be responsible for its anti-HCC potential.
|
31129132 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT.
|
31409969 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway.
|
31368655 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
L02 sensitized HCC to IR by the activation of P53 signaling, the decrease in Bcl-2, up-regulation of cytochrome c and the subsequent activation of caspase-3.
|
30445021 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CONCLUSIONS This study suggest that 125I-IBT inhibits tumor growth via upregulating caspase-3 expression and prompting apoptosis in HCC HepG2 xenografts.
|
30636171 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In vitro studies were done using the human hepatocellular carcinoma (Hep G2) cell line for validating the efficacy of liposomal siRNA in controlling the expression of genes (Caspase 3 and ADAMTS5).
|
30439528 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
BER significantly reduced doxorubicin (DOX)-triggered HCC repopulation in vitro and in vivo through inhibiting Caspase-3-iPLA2-COX-2 pathway.
|
31563690 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis.
|
30660690 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusions</b>: Our study is the first one reporting data of circulating caspase-3 levels prior to LT for HCC, and an association between high serum caspase-3 levels previously to LT and survival at first year after LT.
|
31084510 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The obtained data revealed that administration of Mel before MSCs treatment without preconditioning yielded a better ameliorative effect against DEN-induced hepatocellular carcinoma (HCC) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione S-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes Bax and caspase 3 and downregulated expression of anti-apoptotic genes Bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa B, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene.
|
30925457 |
2019 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity.
|
31300048 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the combination of low-toxic PCP and Cu(OP)2 (0-1.6 µM; PCP/Cu(OP)2 molar ratio: 2:1) induces a concentration-dependent intracellular copper accumulation, apoptosis, caspase-3/9 activation, depolarization of mitochondrial membrane potential, and oxidative stress (reactive oxygen species increasing and glutathione/oxidized glutathione ratio decreasing) in both normal hepatocytes HL-7702 and hepatocarcinoma HepG2 cells.
|
30590774 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Finally, we found that inhibition of p38 by SB202190 abrogated enhanced hepatocyte death, compensatory proliferation and HCC induced by DEN in Caspase-3-deficient mice.
|
29752472 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to investigate the effect of Solanum nigrum polysaccharides (SNPs) on tumor growth in H22 hepatocarcinoma cells bearing mice and explore the mechanism by focusing on the regulation of the expression of caspase-3 and bcl-2.
|
29578179 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-β1 expression in hepatocellular carcinoma-induced in rats.
|
30205014 |
2018 |
Liver carcinoma
|
0.300 |
Therapeutic
|
disease |
RGD |
Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model.
|
29133031 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A significant reduction in the serum concentration levels LC3 and caspase-3 were observed referring to the down regulation of autophagy and host-mediated apoptosis in HCV patients with or without HCC.
|
29561429 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In vivo study showed that AC68 significantly inhibited tumor growth in HCC mouse xenograft model, and induced apoptosis by increasing the expression of cleaved caspase-3.
|
29253760 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, caspase-3 activity detection, and flow cytometry were performed to examine growth, proliferation, and apoptosis of hepatocarcinoma cell line MHCC97H, respectively.
|
30280770 |
2018 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although we recently demonstrated that cytoplasmic AFP might interact with caspase-3 and inhibit the signal transduction of apoptosis in human hepatocellular carcinoma (HCC) cells, the details of this interaction are not clear.
|
28653316 |
2017 |