CASP3, caspase 3, 836

N. diseases: 819; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE CCK-8, EdU, transwell, western blot and caspase-3 activity analyses were utilized to testify the role of LINC00467 in HCC. 31656043 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE Furthermore, Chrysin was able to increase caspase-3 activity in the HCC rats group (about 2.4 fold) compared to the normal rats group. 31708277 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE In addition to melanoma, the DGKα inhibitors enhanced caspase 3/7 activity and reduced the viability of hepatocellular carcinoma, glioblastoma, and pancreatic cancer cells, but not breast adenocarcinoma cells. 30536880 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2. 30725182 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE SCL2A9 induced HCC cell apoptosis by inhibiting the expression of caspase 3. 29523220 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE The result confirmed that the HCC condition was developed in response to lower expressions of caspase 3 and 9 which, in turn, was due to the upstream regulation of iNOS, Bcl-xl and Bcl-2, and downstream regulation of eNOS, BAX, BAD and Cyt C. The treatment with ZOL caused the significant activation of caspase mediated apoptotic signals that could be responsible for its anti-HCC potential. 31129132 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT. 31409969 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway. 31368655 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE L02 sensitized HCC to IR by the activation of P53 signaling, the decrease in Bcl-2, up-regulation of cytochrome c and the subsequent activation of caspase-3. 30445021 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE CONCLUSIONS This study suggest that 125I-IBT inhibits tumor growth via upregulating caspase-3 expression and prompting apoptosis in HCC HepG2 xenografts. 30636171 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE In vitro studies were done using the human hepatocellular carcinoma (Hep G2) cell line for validating the efficacy of liposomal siRNA in controlling the expression of genes (Caspase 3 and ADAMTS5). 30439528 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE BER significantly reduced doxorubicin (DOX)-triggered HCC repopulation in vitro and in vivo through inhibiting Caspase-3-iPLA2-COX-2 pathway. 31563690 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis. 30660690 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE <b>Conclusions</b>: Our study is the first one reporting data of circulating caspase-3 levels prior to LT for HCC, and an association between high serum caspase-3 levels previously to LT and survival at first year after LT. 31084510 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE The obtained data revealed that administration of Mel before MSCs treatment without preconditioning yielded a better ameliorative effect against DEN-induced hepatocellular carcinoma (HCC) as evidenced by: 1) reduced serum levels of alpha fetoprotein and gamma-glutamyl transferase; 2) decreased number and area of glutathione S-transferase placental positive foci; 3) induced apoptosis (as indicated by increased cleaved caspase-3 activity, upregulated expression of proapoptotic genes Bax and caspase 3 and downregulated expression of anti-apoptotic genes Bcl2, survivin); 4) decreased malondialdehyde level and increased activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes; and 5) reduced inflammation, angiogenesis and metastasis as indicated by downregulated expression of interleukin 1 beta, nuclear factor kappa B, vascular endothelial growth factor, and matrix metallopeptidase 9 genes and upregulated expression of metalloproteinase inhibitor 1 gene. 30925457 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity. 31300048 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE We demonstrate that the combination of low-toxic PCP and Cu(OP)2 (0-1.6 µM; PCP/Cu(OP)2 molar ratio: 2:1) induces a concentration-dependent intracellular copper accumulation, apoptosis, caspase-3/9 activation, depolarization of mitochondrial membrane potential, and oxidative stress (reactive oxygen species increasing and glutathione/oxidized glutathione ratio decreasing) in both normal hepatocytes HL-7702 and hepatocarcinoma HepG2 cells. 30590774 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE Finally, we found that inhibition of p38 by SB202190 abrogated enhanced hepatocyte death, compensatory proliferation and HCC induced by DEN in Caspase-3-deficient mice. 29752472 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE The objective of this study was to investigate the effect of Solanum nigrum polysaccharides (SNPs) on tumor growth in H22 hepatocarcinoma cells bearing mice and explore the mechanism by focusing on the regulation of the expression of caspase-3 and bcl-2. 29578179 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE Vitamin D potentiates anti-tumor activity of 5-fluorouracil via modulating caspase-3 and TGF-β1 expression in hepatocellular carcinoma-induced in rats. 30205014 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Therapeutic disease RGD Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. 29133031 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE A significant reduction in the serum concentration levels LC3 and caspase-3 were observed referring to the down regulation of autophagy and host-mediated apoptosis in HCV patients with or without HCC. 29561429 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE In vivo study showed that AC68 significantly inhibited tumor growth in HCC mouse xenograft model, and induced apoptosis by increasing the expression of cleaved caspase-3. 29253760 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 AlteredExpression disease BEFREE 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, caspase-3 activity detection, and flow cytometry were performed to examine growth, proliferation, and apoptosis of hepatocarcinoma cell line MHCC97H, respectively. 30280770 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.300 Biomarker disease BEFREE Although we recently demonstrated that cytoplasmic AFP might interact with caspase-3 and inhibit the signal transduction of apoptosis in human hepatocellular carcinoma (HCC) cells, the details of this interaction are not clear. 28653316 2017