|
Medulloblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
|
Medullomyoblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
|
Childhood Medulloblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
|
Adult Medulloblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
|
Desmoplastic Medulloblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
|
Melanotic medulloblastoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
|
Major Depressive Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
|
29700475 |
2018 |
|
Major Depressive Disorder
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We found that common and rare variants of L3MBTL2 were significantly associated with AD. mRNA expression levels of 18 MDD risk genes, in particular SORCS3 and OAT, were differentially expressed in AD brain tissues.
|
30010129 |
2018 |
|
Major Depressive Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
|
27479909 |
2016 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The tumor suppressor L(3)mbt has been shown to secure cellular identity in <i>Drosophila</i> larval brains by repressing germline-specific genes.
|
29511022 |
2018 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors.
|
24243547 |
2014 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.
|
21857667 |
2011 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia.
|
20585043 |
2010 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors.
|
15334543 |
2004 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Homozygous mutations in the l(3)mbt gene cause brain tumors in Drosophila, identifying l(3)mbt as a tumor suppressor gene.
|
12588862 |
2003 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
The lethal(3)malignant brain tumor (D-l(3)mbt) gene is considered to be one of the tumor suppressor genes of Drosophila, and its recessive mutations are associated with malignant transformation of the neuroblasts in the larval brain.
|
10445843 |
1999 |
|
Brain Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we show that <i>Drosophila</i> l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females.
|
31453329 |
2019 |
|
Malignant neoplasm of brain
|
0.040 |
Biomarker
|
disease |
BEFREE |
Lethal (3) malignant brain tumor like 2 (L3MBTL2) is a member of the MBT-domain proteins, which are involved in transcriptional repression and implicated in chromatin compaction.
|
30760872 |
2019 |
|
Malignant neoplasm of brain
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the lethal (3) malignant brain tumor gene (l(3)mbt) have been shown to cause ectopic expression of germline genes, including ping-pong factors.
|
28552546 |
2017 |
|
Brain Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors.
|
24243547 |
2014 |
|
Brain Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We demonstrate that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway.
|
21857667 |
2011 |
|
Malignant neoplasm of brain
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors.
|
15334543 |
2004 |