|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease.
|
27911442 |
2017 |
|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
The molecular details of caspase-6 dynamics in solution provide a comprehensive scaffold for strategic design of therapeutic approaches for neurodegenerative disorders.
|
28864531 |
2017 |
|
Neurodegenerative Disorders
|
0.080 |
AlteredExpression
|
group |
BEFREE |
This study provides a first mechanistic explanation for the key regulatory role of Trx1 as a gatekeeper in activation of CASP6 and induction of nuclear invagination, an important player in ND pathophysiology.
|
30769159 |
2019 |
|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
Fipronil induced apoptosis involving caspase-6, which is an apoptotic effector highly implicated in neurodegenerative diseases.
|
28322794 |
2017 |
|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors have been exclusively studied in vitro or show acute liver toxicity in humans.
|
28241839 |
2017 |
|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
Noteworthy patents include a peptidic caspase-2 inhibitor for nasal administration and a peptidomimetic caspase-6 inhibitor that can be administered via several routes for the treatment of neurodegenerative diseases.
|
28885866 |
2018 |
|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
The results indicate age and neuronal subtype-dependent Caspase-6 toxicity and highlight the importance of targeting the correct neuronal subtype to identify underlying molecular mechanisms of neurodegenerative diseases.
|
29352267 |
2018 |
|
Neurodegenerative Disorders
|
0.080 |
Biomarker
|
group |
BEFREE |
In particular, numerous findings implicate Caspase-6 (Casp6) in neurodegenerative diseases, including Alzheimer disease (AD) and Huntington disease (HD), highlighting the need for a deeper understanding of Casp6 biology and its role in brain development.
|
22262731 |
2012 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
This work explores the effect of CASP6 tumor-associated mutations on the catalytic efficiency and structure of caspase-6.
|
28726391 |
2017 |
|
Neoplasms
|
0.070 |
GeneticVariation
|
group |
BEFREE |
Differentially regulated genes included thymosin beta-10, fibroblast growth factor receptor 4, aldo-keto reductase and caspase 6 genes, which are known to be associated with tumor development and progression.
|
14611677 |
2003 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Fine mapping of this region with possible tumor suppressor gene suggests caspase 6 as a putative tumor suppressor gene.
|
15942683 |
2005 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Similar to the results of our previous research on e23sFv-PEA II-casp6, the delivery of liposome-encapsulated e23sFv-Fdt-casp6 constructs in tumor-adjacent muscles also inhibited tumor growth and prolonged animal survival in a nude mouse xenograft tumor model.
|
21767874 |
2011 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Analysis of the dataset also reveals the unexpected downregulation of caspase-3 and an upregulation of caspase-6 in addition to a global upregulation of lysosomal proteins in the bulk of the tumor.
|
28508578 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors.
|
15210759 |
2004 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Our data showed that the immuno-casp-6 can specifically recognize HER2-overexpressing osteosarcoma cells, can also promptly attack their nucleus and induce apoptotic death, suggesting the potential of this strategy for the treatment of human HER2-overexpressing tumors.
|
23135254 |
2013 |
|
Impaired cognition
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results suggest that full Casp6 activity may not be essential for healthy humans and support the use of Casp6 inhibitors against Casp6-dependent neurodegeneration in age-dependent cognitive impairment and AD.
|
29535332 |
2018 |
|
Impaired cognition
|
0.040 |
Biomarker
|
disease |
BEFREE |
The effect of inhibitors on age-dependent cognitive deficits in Caspase-6 transgenic mice was assessed by the novel object recognition task.
|
28241839 |
2017 |
|
Impaired cognition
|
0.040 |
Biomarker
|
disease |
BEFREE |
The Caspase-6 expressing mice and control littermates were subjected to behavioral tests to assess Huntington disease-relevant psychiatric, motor, and cognitive deficits.
|
29352267 |
2018 |
|
Impaired cognition
|
0.040 |
Biomarker
|
disease |
BEFREE |
Therefore, methylene blue reverses Caspase-6-induced cognitive deficits by inhibiting Caspase-6, and Caspase-6-mediated neurodegeneration and neuroinflammation.
|
31843022 |
2019 |
|
Cognition Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
The effect of inhibitors on age-dependent cognitive deficits in Caspase-6 transgenic mice was assessed by the novel object recognition task.
|
28241839 |
2017 |
|
Cognition Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
The Caspase-6 expressing mice and control littermates were subjected to behavioral tests to assess Huntington disease-relevant psychiatric, motor, and cognitive deficits.
|
29352267 |
2018 |
|
Cognition Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Therefore, methylene blue reverses Caspase-6-induced cognitive deficits by inhibiting Caspase-6, and Caspase-6-mediated neurodegeneration and neuroinflammation.
|
31843022 |
2019 |
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
|
21677173 |
2011 |
|
Cerebrovascular accident
|
0.030 |
Biomarker
|
group |
BEFREE |
Caspase-6 (casp6) in particular has been shown to play a key role in the pathogenesis of stroke, Huntington disease, and Alzheimer disease.
|
29193273 |
2018 |
|
Cerebrovascular accident
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Decreasing CASP6 activity may help to restore neuronal function in these and other diseases such as stroke and ischemia, where increased CASP6 activity has been implicated.
|
27911442 |
2017 |