MAGT1, magnesium transporter 1, 84061

N. diseases: 120; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 AlteredExpression group BEFREE Overexpression of IAP proteins has been documented in various solid and hematological malignancies, rendering them resistant to standard chemotherapeutics and radiation therapy and conferring poor prognosis. 29067538 2017
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 Biomarker group BEFREE Further insights into the signaling pathways that are under the control of IAP proteins and into the specific IAP protein-dependent vulnerabilities of hematological neoplasms are expected to pave the avenue to novel treatment strategies. 24487414 2014
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 AlteredExpression group BEFREE Survivin, a member of the inhibitor of apoptosis (IAP) proteins and chromosome passenger complex, is expressed in hematologic malignancies and overexpressed in relapsed pediatric ALL. 21960246 2012
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 GeneticVariation group BEFREE Given their role in the development and progression of solid tumors and hematologic malignancies, efforts are underway to develop therapeutic IAP inhibitors, with a focus on X-linked IAP (XIAP) and survivin. 16304383 2005