TAGLN2, transgelin 2, 8407

N. diseases: 64; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 AlteredExpression disease BEFREE The transcriptional levels of TAGLN2 in HBV-HCC tissues and their adjacent tissues were positively related to that of HBc, HBs and HBx (P < 0.05). 27402267 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 Biomarker disease CTD_human These identified proteins, which include stratifin (14-3-3), transgelin 2, heat-shock protein (HSP)70, HSP27, manganese superoxide dismutase, prohibitin, DJ1, α-enolase, peroxiredoxin 6, aldo-keto reductase family member B10, phosphoglycerate kinase 1, α-1-antitrypsin and nm23-H1, may play a role in the development of HCC. 21472284 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 Biomarker disease BEFREE Site-directed mutagenesis of TAGLN2 suggested that PFTK1 regulates the actin-binding affinity of TAGLN2 through the S83 and S163 residues, which if mutated can significantly affect HCC cell motility. 21577206 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.330 AlteredExpression disease BEFREE The overexpression of transgelin 2 mRNA in a large per cent (69%) of HCC points to its potential as a diagnostic marker for HCC. 15756260 2005
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.310 Biomarker disease BEFREE Our data demonstrated that TAGLN2 might be an HBx induced positive host factor involved in HBV transcription and replication and HBx related liver fibrosis and tumorigenesis. 27402267 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.310 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.300 Biomarker phenotype CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Chemical and Drug Induced Liver Injury
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
Conventional (Clear Cell) Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
CUI: C1266042
Disease: Chromophobe Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
CUI: C1266043
Disease: Sarcomatoid Renal Cell Carcinoma
Sarcomatoid Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
Collecting Duct Carcinoma of the Kidney
0.300 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
CUI: C1306837
Disease: Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma
0.300 Biomarker disease CTD_human Differential protein profiling in renal-cell carcinoma. 15108329 2004
Platelet mean volume determination (procedure)
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Platelet Component Distribution Width Measurement
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE Transgelin 2 has recently been shown to induce drug resistance, tumor migration, and invasion. 31488699 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.090 Biomarker group BEFREE The present study proposed TAGLN2 to function as a tumor suppressor and that loss of TAGLN2 may promote the metastasis of breast cancer by activating the ROS/NF‑κB signaling pathway. 31485630 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.090 AlteredExpression phenotype BEFREE Transgelin 2 overexpression inhibits cervical cancer cell invasion and migration. 30942422 2019