Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data indicate that PIM1 inhibition and ABT-737 synergistically induce apoptosis in an MCL1-independent but CASP8-dependent manner in GB.
|
30389373 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, TNFα-induced protein 3 (TNFAIP3, A20) was reported to prevent TRAIL-induced caspase 8 cleavage in the DISC by mediating ubiquitination of RIP1 in glioblastoma.
|
29274253 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore hypothesised that improving caspase-8 activation or sensitising mitochondria to truncated Bid (tBid) could convert non-responder GBM cell lines to responders.
|
30385739 |
2018 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Intriguingly, other tumors, such as glioblastoma, preferentially retain Caspase-8 expression, and high levels of Caspase-8 expression may correlate with a worse prognosis, suggesting that in this context this protease loses its apoptotic activity and gains additional functions.
|
30501030 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correlations between the expressions of FADD and Caspase-8 in GBM tissues were analyzed as being linked with the clinical grades of GBM patients.
|
28618251 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have recently shown that Caspase-8 sustains neoplastic transformation in vitro in human GBM cell lines.
|
28594322 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that 3TSR upregulates death receptor (DR) 4/5 expression in a CD36-dependent manner and primes resistant GBMs to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-8/3/7 mediated apoptosis.
|
25358253 |
2015 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The methylation status of MGMT, CD81, GATA6, DR4, and CASP8 in 76 patients with primary glioblastomas was investigated.
|
22672670 |
2012 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Western blotting and immunohistochemistry of human glioblastoma tumors demonstrated the expression of caspase-8 protein in the vast majority of the tumors as compared to normal human brain tissues that lack the caspase-8 expression.
|
21877214 |
2011 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the DISC, caspase-8 was cleaved and initiated apoptosis by cleaving downstream caspases in TRAIL-sensitive glioblastoma cells.
|
19432816 |
2010 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Small interfering RNA (siRNA)-mediated transcriptional knockdown of urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9), alone or in combination, inhibits uPAR and/or MMP-9 expression and induces apoptosis in the human glioblastoma xenograft cell lines 4910 and 5310. siRNA against uPAR (pU-Si), MMP-9 (pM-Si), or both (pUM-Si) induced apoptosis and was associated with the cleavage of caspase-8, caspase-3, and poly(ADP-ribose) polymerase.
|
20716639 |
2010 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma.
|
18812519 |
2009 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
|
17272309 |
2007 |
Glioblastoma
|
0.100 |
PosttranslationalModification
|
disease |
LHGDN |
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.
|
17272309 |
2007 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that, differently from glioma cell lines, glioblastoma multiforme tumors were resistant to TRAIL stimulation because they expressed low levels of caspase-8 and high levels of the death receptor inhibitor PED/PEA-15.
|
16357155 |
2005 |