|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination treatment of MSC-TRAIL and compound C increased apoptosis by enhancing expression of B-cell lymphoma 2 (BCL2)-associated X protein (BAX) and reducing that of anti-apoptotic proteins cellular FLICE-inhibitory protein (FLIP), X-linked inhibitor of apoptosis (XIAP), and BCL2 in glioma.
|
31810928 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Flowcytometry, immunoblotting, and immunofluorescence imagining results revealed multi potent T11TS not only significantly downregulates gliomagenic overexpression of Fas, Fas L, Bid, and caspase-8, the pro-apoptotic extrinsic mediators but also strongly inhibits cytosolic release of cytochrome-c, Apf-1, and Bax to deactivate gliomagenic caspase-9, 3 the key intrinsic apoptotic mediators followed by up modulation of anti-apoptotic Bcl-2 in glioma associated HSCs.
|
28233371 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, we have reported that Demethoxycurcumin induced Reactive oxygen species via inhibition of Mitochondrial Superoxide Dismutase is an initial event to trigger apoptosis through caspase-8 and 9 activation and to inhibit Akt/NF-κB survival signaling in human glioma U87 MG cells (Kumar et al., 2018).
|
30009775 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, SIRT6 restoration led to apoptosis with alterative expression of Bax, Bcl-2, cleaved caspase-8, and inhibition of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway in glioma.
|
28677777 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of caspase-8 at the mRNA level was significantly associated with the grade of human glioma.
|
28204824 |
2017 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
D302H polymorphism of CASP8 gene may be associated with increased risk of glioma but larger study groups in different ethnic populations are needed to better elucidate the role of CASP8 gene polymorphism in the pathogenesis of primary brain tumors.
|
26359420 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, it is evident from our results that MMP-2 downregulation induces caspase-8 and AIF-mediated apoptosis and, as such, shows potential for glioma therapy.
|
19724922 |
2009 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.
|
18398042 |
2008 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The CT haplotype of the two CASP8 polymorphisms was associated with significantly increased risk of meningioma (OR, 1.7; 95% CI, 1.1-2.6), but was not associated with risk of glioma or acoustic neuroma.
|
17684142 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that, differently from glioma cell lines, glioblastoma multiforme tumors were resistant to TRAIL stimulation because they expressed low levels of caspase-8 and high levels of the death receptor inhibitor PED/PEA-15.
|
16357155 |
2005 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis.
|
14991747 |
2004 |