CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Medulloblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 AlteredExpression disease BEFREE It is important to note that VA and IFN-gamma restore caspase-8 expression and sensitivity to TRAIL in primary medulloblastoma samples and significantly potentiate TRAIL-mediated suppression of medulloblastoma growth in vivo. 19597472 2009
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 Biomarker disease BEFREE LD(50) treatment of medulloblastoma cells with perifosine led to the cleavage of caspase 9, caspase 7, caspase 3, and poly-ADP ribosylation protein, although caspase 8 was not detectable. 19887560 2009
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 Biomarker disease BEFREE Caspase-8 is frequently deleted or silenced in neuroblastoma and other solid tumor such as medulloblastoma and small cell lung carcinoma. 18342014 2008
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 AlteredExpression disease LHGDN Thus, by demonstrating that 5-dAzaC and IFN-gamma at relatively low individual concentrations cooperate to restore caspase-8 expression and sensitize resistant neuroblastoma and medulloblastoma cells to TRAIL-induced apoptosis, our findings have important implications for novel strategies targeting defective apoptosis pathways in neuroectodermal tumors. 16607283 2006
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 AlteredExpression disease BEFREE Thus, by demonstrating that 5-dAzaC and IFN-gamma at relatively low individual concentrations cooperate to restore caspase-8 expression and sensitize resistant neuroblastoma and medulloblastoma cells to TRAIL-induced apoptosis, our findings have important implications for novel strategies targeting defective apoptosis pathways in neuroectodermal tumors. 16607283 2006
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 Biomarker disease BEFREE Recent studies have identified a series of candidate tumor suppressor genes (for example, RASSF1A, CASP8, and HIC1) that are each specifically epigenetically inactivated in a large proportion (> 30%) of medulloblastomas by promoter hypermethylation, leading to the silencing of their gene expression. 16398460 2005
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 Biomarker disease BEFREE To evaluate the role of tumor suppressor genes caspase-8 (CASP8), TIMP-3, E-cadherin (CDH1), p16INK4A, and MGMT in medulloblastoma tumorigenesis, 51 medulloblastomas (46 primary tumor specimens, 5 cell lines) were screened for methylation of promoter linked CpG-islands. 15029256 2004
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 PosttranslationalModification disease BEFREE Our findings suggest that methylation commonly contributes to CASP8 silencing in medulloblastomas and that homozygous deletion or severe sequence changes involving the promoter region may be another mechanism leading to CASP8 inactivation in this neoplasm. 15289853 2004
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.080 Biomarker disease BEFREE These data therefore indicate that extensive methylation of RASSF1A, HIC1 and CASP8 are tumour-specific events in medulloblastoma. 14688019 2004