CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.470 GeneticVariation disease BEFREE Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 data sets confirmed 20 single-nucleotide polymorphisms across 10 loci (TYR, AFG3L1P, CDK10, MYH7B, SLC45A2, MTAP, ATM, CLPTM1L, FTO, and CASP8) that have previously been published with genome-wide significant evidence for association (P<5 × 10(-8)) with CM risk, with certain variants possibly functioning as proxies of already tagged genes. 25407435 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.470 GeneticVariation disease GWASDB Genome-wide association study identifies three new melanoma susceptibility loci. 21983787 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.470 Biomarker disease CTD_human Genome-wide association study identifies three new melanoma susceptibility loci. 21983787 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.470 Biomarker disease BEFREE RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway. 19684859 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.470 Biomarker disease CTD_human Therefore, these CASP8 and CASP10 polymorphisms may be biomarkers for susceptibility to CM. 18563783 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.470 Biomarker disease LHGDN Therefore, these CASP8 and CASP10 polymorphisms may be biomarkers for susceptibility to CM. 18563783 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.470 Biomarker disease BEFREE Therefore, these CASP8 and CASP10 polymorphisms may be biomarkers for susceptibility to CM. 18563783 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.470 AlteredExpression disease BEFREE Methylation and deletion of Apaf-1 and CASP8 results in the loss of their expression in melanoma and neuroblastoma, respectively, while CASP9 localization to 1p36.1 suggests it is a good candidate tumor suppressor. 11896617 2002
CUI: C0025202
Disease: melanoma
melanoma 		0.470 Biomarker disease BEFREE These data suggest that GSNp85 is a cleavage product of caspase-8 and may be useful as a new marker for the vertical or metastatic growth phase of malignant melanoma. 12459641 2002
CUI: C0025202
Disease: melanoma
melanoma 		0.470 PosttranslationalModification disease BEFREE Subsequently others have also shown that caspase-8 is silenced by methylation in neuroblastoma and peripheral neural ectodermal tumors, and that the caspase-9 regulator Apaf-1 is silenced by methylation in melanoma cell lines and patient samples. 11511973 2001
CUI: C0025202
Disease: melanoma
melanoma 		0.470 AlteredExpression disease BEFREE Here, we report in a variety of different tumor cells including Ewing tumor, neuroblastoma, malignant brain tumors and melanoma that caspase-8 expression acts as a key determinant of sensitivity for apoptosis induced by death-inducing ligands or cytotoxic drugs. 11593392 2001