CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Small cell carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 GeneticVariation disease BEFREE Three SNPs, CASP8: rs1045494 (C > T), PIK3R1: rs3756668 (A > G) and CASP7: rs4353229 (T > C), were associated with longer overall survival in LD-SCLC patients after chemoradiotherapy. 26988918 2016
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 Biomarker disease BEFREE The results show that adenoviral delivery of TIMP-3 promotes apoptotic cell death in SCLC cells in the absence of caspase-8 activation. 20473894 2011
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 AlteredExpression disease BEFREE Treatment of SCLC cells with interferon-gamma (IFN-gamma) restored caspase-8 expression and facilitated TRAIL-induced apoptosis. 18093694 2008
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 AlteredExpression disease BEFREE Here we show that four different retinoic acid (RA) derivatives also increase caspase-8 protein expression in neuroblastoma, medulloblastoma and small cell lung carcinoma cell lines. 18342014 2008
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 GeneticVariation disease BEFREE These findings suggest that the CASP-8 gene may contribute to an inherited predisposition to SmCC of the lung. 16938569 2006
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 Biomarker disease LHGDN Analysis of SCLC tumors revealed reduced levels of Fas, TRAIL-R1 and caspase-8 mRNA compared to non-small cell lung cancer (NSCLC) tumors. 12700635 2003
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 GeneticVariation disease BEFREE Methylation of the promoter region of the CASP8 gene was present in 16 of 27 (59%) of the SCLC lines lacking gene expression. 12170765 2002
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 Biomarker disease BEFREE Since caspase-8 is essential for signal transduction of death receptor-mediated apoptosis, all known death receptor systems are thus not required for drug-induced apoptosis in SCLC. 11807782 2002
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.090 AlteredExpression disease BEFREE CASP8 gene expression was frequently lost (79%) at message and protein levels in SCLC but not in non-SCLC (NSCLC). 12466971 2002