CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Acute glaucoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0281773
Disease: Acute glaucoma
Acute glaucoma 		0.020 Biomarker disease BEFREE Kaempferol attenuated retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via inhibiting NF-κB and JNK pathways in acute glaucoma. 30560913 2019
CUI: C0281773
Disease: Acute glaucoma
Acute glaucoma 		0.020 Biomarker disease BEFREE These findings demonstrate collectively a critical role of caspase-8 in transducing TLR4-mediated IL-1β production and RGC death and highlight signal transduction in a caspase-1-dependent NLRP1/NLRP3 inflammasome pathway and a caspase-1-independent pathway in acute glaucoma. 25024200 2014