Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We established N-myc-downregulated IMR-32 cells using shRNA lentiviral particles targeting N-myc and examined the effect the N-myc inhibition on TRAIL susceptibility in human neuroblastoma IMR-32 cells expressing caspase-8.
|
30724400 |
2019 |
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Contrarily, the presence of the -652 6N Del or the CASP8 302His variant was reported to be an unfavorable prognostic factor in colorectal cancer or neuroblastoma.
|
27507139 |
2016 |
Central neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A missense SNP in exon 10 of the CASP8 gene SNP D302H was associated with worse overall and event-free survival in patients with MYCN-amplified neuroblastoma tumors.
|
25502557 |
2014 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subcellular fractionation analysis revealed caspase-8 activity in both cytosol and plasma membrane fractions in both NB7 reconstituted caspase-8 cell lines, as well the LNCaP prostate cancer cells.
|
23456622 |
2013 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exogenous interferon-γ upregulated expression of caspase-8 in 3 of 4 neuroblastoma cell lines and increased the contribution of TRAIL to NK cytotoxicity against 2 of the 3 lines; however, relatively little inhibition of cytotoxicity was observed when activated NK cells were treated with an anti-interferon-γ neutralizing antibody.
|
23719242 |
2013 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The combined data suggest that FOXO3 is activated by 5-azadC treatment and triggers expression of caspase-8 in caspase-8-negative neuroblastoma, which may have important implication for metastasis, therapy, and death resistance of this childhood malignancy.
|
22493319 |
2012 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic alterations have been described as well: caspase-8 (CASP8) and RAS-association domain family 1 isoform A (RASSF1A) DNA-methylation are important events for the development and progression of neuroblastoma.
|
21725203 |
2011 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose the simultaneous analysis of hypermethylation of APAF1, TMS1 and CASP8 apoptotic genes on primary NB tumour as a good prognostic factor of disease progression.
|
21104989 |
2011 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The relative caspase 8 activity of NB cells expressing caspase 8 increased with the prolongation of TRAIL action time.
|
19954364 |
2009 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array.
|
19260109 |
2009 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we show that four different retinoic acid (RA) derivatives also increase caspase-8 protein expression in neuroblastoma, medulloblastoma and small cell lung carcinoma cell lines.
|
18342014 |
2008 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that the pattern of expression of these neural-enriched IG20-SVs regulates the expression and activation of caspase-8 in certain neuroblastoma cells, and that manipulation of IG20-SV expression pattern may represent a potent therapeutic strategy in the therapy of neuroblastoma and perhaps other cancers.
|
18794122 |
2008 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a, p16INK4a, p14ARF, APC, RB1, RASSF1A, BLU, FHIT, RARbeta, INI1, TIMP3, NF2, MGMT, DAPK, FLIP, ECAD, CASP8, and the receptors DcR1 and DcR2).
|
17570703 |
2008 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Re-expression of caspase-8 in neuroblastoma cells lacking endogenous caspase-8 expression was found to promote cell adhesion to extracellular matrix and to activate adhesion-dependent signaling pathways, such as the Erk kinase cascade.
|
18089800 |
2007 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells.
|
17036321 |
2007 |
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma.
|
17064406 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
|
16886176 |
2006 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings define caspase-8 as a metastasis suppressor gene that, together with integrins, regulates the survival and invasive capacity of neuroblastoma cells.
|
16397500 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether the levels of survivin and caspase 8 and the ratio between these 2 apoptotic factors correlate with tumor biology and predicts outcome in patients with neuroblastoma.
|
16825985 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We sought to determine whether caspase 8l is present in neuroblastoma and whether over-expression of this protein could inhibit caspase 8-dependent apoptosis.
|
16374545 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, by demonstrating that 5-dAzaC and IFN-gamma at relatively low individual concentrations cooperate to restore caspase-8 expression and sensitize resistant neuroblastoma and medulloblastoma cells to TRAIL-induced apoptosis, our findings have important implications for novel strategies targeting defective apoptosis pathways in neuroectodermal tumors.
|
16607283 |
2006 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By revealing no correlation between caspase-8 expression and MYCN amplification or other established variables of aggressive disease, our findings in a large cohort of neuroblastoma patients show that inactivation of caspase-8 is not a characteristic feature of aggressive neuroblastoma.
|
17047064 |
2006 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the methylation pattern of 14.3.3sigma, RASSF1A and of an intragenic segment of CASP8 was significantly different between MYCN amplified and single copy neuroblastoma suggesting a specific role of epigenetic alterations in aggressive neuroblastoma.
|
16044164 |
2005 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, gemcitabine-induced apoptosis was observed irrespective of the caspase-8 status of neuroblastoma cells, which indicates that apoptosis depends on the mitochondrial pathway.
|
15867251 |
2005 |
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that restoration of active caspase-8 expression in a caspase-8-deficient NB cell line is necessary and sufficient to fully restore TRAIL sensitivity.
|
15094781 |
2004 |