|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Fibrosis, Liver
|
0.040 |
Biomarker
|
disease |
BEFREE |
NLRC5 inhibition would be a promising therapeutic avenue for treating hepatic fibrosis.
|
26592197 |
2016 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
NLRC5/MHC class I transactivator is a target for immune evasion in cancer.
|
27162338 |
2016 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
NLRC5/MHC class I transactivator is a target for immune evasion in cancer.
|
27162338 |
2016 |
|
Fibrosis, Liver
|
0.040 |
Biomarker
|
disease |
BEFREE |
NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLRs) family, has recently been implicated in the development of hepatic fibrosis.
|
27525969 |
2016 |
|
Chronic Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NLRC5 polymorphism is associated with susceptibility to chronic periodontitis.
|
28122660 |
2017 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
NLRC5 deficiency does not affect the generation of antigen-specific CD8<sup>+</sup> T cells following IAV infection; however, a change in epitope dominance is observed in <i>Nlrc5</i><sup>-/-</sup> mice.
|
28615208 |
2017 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NLRC5 was highly expressed in kidney from streptozotocin-induced diabetic mice, db/ db mice and patients with diabetes.
|
29070585 |
2018 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
NLRC5 was highly expressed in kidney from streptozotocin-induced diabetic mice, db/ db mice and patients with diabetes.
|
29070585 |
2018 |
|
Diabetic Nephropathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLR) family, was involved in various physiological processes, such as inflammation, fibrosis, innate immunity and diabetic nephropathy.
|
29655162 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
NLRC5 is an interferon γ-inducible protein, which plays a role in immune surveillance with a potential influence on cancer survival.
|
29762254 |
2018 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
NLRC5 is an interferon γ-inducible protein, which plays a role in immune surveillance with a potential influence on cancer survival.
|
29762254 |
2018 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NLRC5 and autophagy combined may as promising predictors in patients with endometriosis.
|
30316442 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
NLRC5 is closely related to TNM staging and lymph node metastasis of gastric cancer and is an independent risk factor for the prognosis of gastric cancer patients.
|
30426081 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
NLRC5 expression was significantly related to lymph nodes and tumor node metastasis (TNM) staging (χ<sup>2</sup>=6.295; χ<sup>2</sup>=6.268).
|
30426081 |
2018 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
NLRC5, a newly discovered member of the NLR family, has been reported to regulate immune responses and promote cell proliferation, migration, and invasion in hepatocellular carcinoma.
|
30543814 |
2019 |
|
Respiratory Syncytial Virus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A model is therefore proposed in which the host upregulates MHC-I expression during RSV infection directly via the induction of RIG-I and NLRC5 expression.
|
25972545 |
2015 |
|
Fibrosis, Liver
|
0.040 |
Biomarker
|
disease |
BEFREE |
As the largest member of the nucleotide‑binding domain and leucine‑rich repeat (NLR) family, NLRC5 has been shown to be pivotal in the development of hepatic fibrosis.
|
28713900 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Better awareness of the multiple roles of NLRC5 will help to define its overall contribution to immune responses and cancer.
|
28261210 |
2017 |
|
Primary malignant neoplasm
|
0.070 |
Biomarker
|
group |
BEFREE |
Better awareness of the multiple roles of NLRC5 will help to define its overall contribution to immune responses and cancer.
|
28261210 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
By contrast, overexpression of NLRC5 promoted the proliferation, migration, and invasion of ccRCC cells in vitro.
|
30543814 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
CITA/NLRC5 plays a crucial role in human cancer immunity through the recruitment and activation of tumor killing CD8+ T cells.
|
30706093 |
2019 |
|
Rotavirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Collectively, our results demonstrate a minor role for NLRC5 in modulating H2-K<sup>b</sup> -restricted antigen-specific CD8<sup>+</sup> T-cell responses in the small intestine during rotavirus infection in adult mice.
|
30768806 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, overexpression of NLRC5 promoted the proliferation, migration and invasion of HCC cells in vitro.
|
26975630 |
2016 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |