Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model. 28515436 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 GeneticVariation phenotype BEFREE The RASSF1AAla133Ser polymorphism, RECK gene polymorphism and for the first time haplotype of both genes influence molecular carcinogenesis and clinic pathological features of HCC within the Egyptian population. 26921475 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE In the present study, we analyzed the state of the MMP-9-RECK axis in cervical carcinogenesis. 26261088 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE HPV16 oncoproteins induce MMPs/RECK-TIMP-2 imbalance in primary keratinocytes: possible implications in cervical carcinogenesis. 22438955 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) has a significant effect on tumorigenesis by limiting angiogenesis and invasion of tumors through the extracellular matrix. 21565829 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE Taken together, we can conclude that hypoxia induces RECK downregulation through the recruitment of HDAC1 and HIF-1alpha to the rHRE2 site in the promoter and the inhibition of hypoxic RECK silencing would be a therapeutic and preventive target for early tumorigenesis. 20080132 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.070 Biomarker phenotype BEFREE RECK regulates MMP-induced pericellular signaling cascades during embryogenesis and tumorigenesis. 12062160 2002