Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 PosttranslationalModification group BEFREE And RECK methylation was closely associated with tumor metastasis in WT patients. 30841433 2019
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 GeneticVariation group BEFREE We verified that HMGB1-induced expression of miR-21 in HCC provides a posttranscriptional repression of the matrix metalloproteinase (MMP) inhibitors RECK and TIMP3, which are known to impact HCC progression and metastases. 25720799 2015
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 AlteredExpression group BEFREE Downregulation of RECK documented in a wide range of malignant neoplasms correlates with poor prognosis, and tumor metastasis. 22292753 2012
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 Biomarker group BEFREE Our previous study demonstrates that HER-2/Neu oncogene inhibits a matrix metalloproteinase inhibitor and tumor metastasis suppressor RECK to promote metastasis. 21255571 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 AlteredExpression group BEFREE Downregulation of RECK was correlated with tumor metastasis (P < 0.01) and shorter patient survival (P < 0.02). 21076843 2011
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 Biomarker group BEFREE In this study, we found that RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373); that RECK mutants lacking the target sites for these miRNA show augmented tumor/metastasis-suppressor activities; and that miR-372/373 are upregulated in response to hypoxia through HIF1alpha and TWIST1, whereas miR-21 is upregulated by RAS/ERK signaling. 20154725 2010
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.070 Biomarker group BEFREE RECK is a membrane-anchored glycoprotein that negatively regulates matrix metalloproteinases (MMPs) and inhibits tumor metastasis and angiogenesis. 12810630 2003