|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype.
|
23707782 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Patients with lung adenocarcinoma (ADC) exhibited significantly more positive staining of HOPX protein compared with lung squamous cell carcinoma (SCC) (p =0.036).
|
25345926 |
2015 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP.
|
18507846 |
2008 |
|
Alloimmunisation
|
0.030 |
Biomarker
|
disease |
BEFREE |
Influenza-infected mice transfused with K1 RBCs developed robust anti-KEL alloantibodies, whereas animals transfused in the absence of infection remained nonresponders; influenza-associated RBC alloimmunization was also observed after transfusion of HOD RBCs.
|
31403208 |
2019 |
|
Alloimmunisation
|
0.030 |
Biomarker
|
disease |
BEFREE |
Experiments completed in an RBC alloimmunization model that allowed evaluation of antigen-specific CD4<sup>+</sup> T-cells (HOD (hen egg lysozyme, ovalbumin, and human duffy<sup>b</sup>)) demonstrated that CD40L blockade prevented the expansion of ovalbumin 323-339 specific T-cells after HOD RBC transfusion and also prevented germinal center formation.
|
28824633 |
2017 |
|
Alloimmunisation
|
0.030 |
Biomarker
|
disease |
BEFREE |
In sum, homozygous β(S) expression and the ensuing disease state are not alone sufficient to enhance RBC alloimmunization to transfused HOD RBCs in two distinct humanized murine models of sickle cell disease under the conditions examined.
|
21790627 |
2012 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
In sum, homozygous β(S) expression and the ensuing disease state are not alone sufficient to enhance RBC alloimmunization to transfused HOD RBCs in two distinct humanized murine models of sickle cell disease under the conditions examined.
|
21790627 |
2012 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to BNP, HOP had better value in discriminating the patients at different stages, especially in elderly patients and those with atrial fibrillation, high body mass index, or kidney dysfunction.
|
30405858 |
2018 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The present study compared the differential prognostic relevance of methylation status of the CDO1 and HOPX genes in BC.
|
31092420 |
2019 |
|
Breast Carcinoma
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
HOPX promoter methylation independently predicted worse prognosis of breast cancer patients.
|
27756570 |
2017 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Compound 3g displayed GI50 value 0.865 μM against EKVX (Non-Small Cell Lung Cancer cell line), and 1.20 µM against MDA-MB-468 (Breast Cancer cell Line), while (4c) showed GI50 value 0.34 and 0.96 µM against HOP-92 and EKVX (Non-Small Cell Lung Cancer cell line) and 1.08 µM against MDA-MB-231/ATCC(Breast Cancer cell Line).
|
29962341 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
These data indicated that miR‑421 may act as an oncogene through the effects of HOPX on the Wnt/β‑catenin signaling pathway and may provide insight into the mechanisms underlying carcinogenesis and the identification of potential biomarkers associated with NSCLC.
|
31115507 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis.
|
22958219 |
2012 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Forced expression of HOP suppressed tumorigenesis in soft agar in four different squamous cell carcinoma cell lines.
|
18234960 |
2008 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Our results demonstrate that HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis.
|
27934959 |
2016 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
In the 60 cell lines of the NCI Developmental Therapeutic Anticancer Screen (the NCI-60), whose whole genome transcriptome and mutations have recently been characterized, we discovered two human lung cancer cell lines deficient for TDP1 (NCI_H522 and HOP_62).
|
24355542 |
2014 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
To analyse the function of HOPX in lung cancer cells, stable transfection with an expression vector of HOPX was performed.
|
25345926 |
2015 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
LOH was only found in 4 out 23 cases (17.4%) indicating that allelic loss is a rare genetic event not responsible for the downregulation of HOP in lung cancer.
|
17417779 |
2007 |
|
Cardiac Arrhythmia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Mutations of genes specific for the developmental processes and/or functional status of cardiac conduction system including ion channel promoter (minK-lacZ), GATA family of zinc finger proteins (GATA4), the homeodomain transcription factor (Nkx2.5), the homeodomain-only protein (Hop) and the T-box transcription factors (Tbx2, Tbx3 and Tbx5), hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) and connexins, may cause fetal arrhythmias.
|
30478614 |
2019 |
|
Cardiomyopathy, Dilated
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Myocardin and HOP mRNA levels were estimated by both northern blot hybridization and semiquantitative RT-PCR in human ventricular preparations in end-stage failure due to dilated cardiomyopathy (DCM), as well as in nonfailing donor hearts.
|
12920479 |
2003 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Myocardin and HOP mRNA levels were estimated by both northern blot hybridization and semiquantitative RT-PCR in human ventricular preparations in end-stage failure due to dilated cardiomyopathy (DCM), as well as in nonfailing donor hearts.
|
12920479 |
2003 |
|
Cardiovascular Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical Practice: The J-HOP Study (Japan Morning Surge-Home Blood Pressure).
|
29133364 |
2018 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The Text-mined Hypertension, Obesity and Diabetes candidate gene database (T-HOD) is developed to help trace existing research on three kinds of cardiovascular diseases: hypertension, obesity and diabetes, with the last disease categorized into Type 1 and Type 2, by regularly and semiautomatically extracting HOD-related genes from newly published literature.
|
23406793 |
2013 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP.
|
18507846 |
2008 |
|
Choriocarcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Loss of NECC1 expression, biallelic deletions at the critical (7p12-7q11.23) region and enhanced H19 expression in choriocarcinoma would reflect the genetic features exhibited by the putative forerunner, complete mole.
|
14614883 |
2003 |