Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
Nerve Degeneration
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
The neuroprotective role of attractin in neurodegeneration.
|
16860906 |
2007 |
Tremor
|
0.200 |
Biomarker
|
phenotype |
RGD |
The myelin vacuolation (mv) rat with a null mutation in the attractin gene.
|
12379762 |
2002 |
Reticulocyte count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.
|
25918132 |
2015 |
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, we showed that cerebrospinal fluid from brain tumor patients induces glioma cell migration and that attractin is largely responsible for this promigratory activity.
|
17085642 |
2006 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
To independently validate these results, we examined attractin expression in a new set of 108 normal and tumoral brain tissue specimens and found elevated expression in 97% of malignant astrocytomas, with the highest levels in grade 4 tumors.
|
17085642 |
2006 |
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
The discovery that a transmembrane form not only controls neuropeptide regulation of hair pigmentation in animals but also affects basal metabolism led to proposals that attractin may also be an extracellular target amenable for the development of obesity-regulating drugs.
|
14994991 |
2004 |
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Attractin presence in glioma, but not in normal glial cells, together with its differential enzymatic activity, suggests its role in growth properties of tumors of glial cell origin.
|
11394875 |
2001 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Attractin/mahogany protein was previously shown to be involved in a number of physiological and pathological events, including immune system regulation, body weight control, pigmentation, myelinization, and tumor susceptibility.
|
11394875 |
2001 |
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
The mahogany protein is a receptor involved in suppression of obesity.
|
10086355 |
1999 |
Leukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
ATRN can now be added to the growing list of genes associated with hypomyelinating leukodystrophy.
|
28493104 |
2017 |
3-Methylglutaconic aciduria type 2
|
0.010 |
Biomarker
|
disease |
BEFREE |
Phenotypic breadth and variability present a major challenge to the diagnostician: some children with BTHS have never been neutropenic, whereas others lack increased 3-MGCA and a minority has occult or absent CM.
|
23398819 |
2013 |
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
Phenotypic breadth and variability present a major challenge to the diagnostician: some children with BTHS have never been neutropenic, whereas others lack increased 3-MGCA and a minority has occult or absent CM.
|
23398819 |
2013 |
Restless Legs Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identified three novel missense and one splice site variant in the PCDHA3, WWC2, ATRN, and FAT2 genes that segregated with RLS in the family.
|
23192925 |
2012 |
3-Methylglutaconic aciduria type 3
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
3-Methylglutaconic aciduria type III (3-MGCA type III), caused by recessive mutations in the 2-exon gene OPA3, is characterized by early-onset bilateral optic atrophy, later-onset extrapyramidal dysfunction, and increased urinary excretion of 3-methylglutaconic acid and 3-methylglutaric acid.
|
20350831 |
2010 |
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) and skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 870 common controls.
|
19384953 |
2009 |
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) and skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 870 common controls.
|
19384953 |
2009 |
Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To independently validate these results, we examined attractin expression in a new set of 108 normal and tumoral brain tissue specimens and found elevated expression in 97% of malignant astrocytomas, with the highest levels in grade 4 tumors.
|
17085642 |
2006 |
Anaplastic astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among 60 cerebrospinal fluid samples of patients with various central nervous system diseases, attractin was consistently found to be elevated in the samples of patients with malignant astrocytoma.
|
17085642 |
2006 |