ATRN, attractin, 8455

N. diseases: 17; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration
0.300 Biomarker phenotype CTD_human The neuroprotective role of attractin in neurodegeneration. 16860906 2007
CUI: C0040822
Disease: Tremor
Tremor
0.200 Biomarker phenotype RGD The myelin vacuolation (mv) rat with a null mutation in the attractin gene. 12379762 2002
CUI: C0206161
Disease: Reticulocyte count (procedure)
Reticulocyte count (procedure)
0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0004096
Disease: Asthma
Asthma
0.100 GeneticVariation disease GWASCAT Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma. 25918132 2015
CUI: C0017638
Disease: Glioma
Glioma
0.020 Biomarker disease BEFREE Finally, we showed that cerebrospinal fluid from brain tumor patients induces glioma cell migration and that attractin is largely responsible for this promigratory activity. 17085642 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 AlteredExpression group BEFREE To independently validate these results, we examined attractin expression in a new set of 108 normal and tumoral brain tissue specimens and found elevated expression in 97% of malignant astrocytomas, with the highest levels in grade 4 tumors. 17085642 2006
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE The discovery that a transmembrane form not only controls neuropeptide regulation of hair pigmentation in animals but also affects basal metabolism led to proposals that attractin may also be an extracellular target amenable for the development of obesity-regulating drugs. 14994991 2004
CUI: C0017638
Disease: Glioma
Glioma
0.020 Biomarker disease BEFREE Attractin presence in glioma, but not in normal glial cells, together with its differential enzymatic activity, suggests its role in growth properties of tumors of glial cell origin. 11394875 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.020 Biomarker group BEFREE Attractin/mahogany protein was previously shown to be involved in a number of physiological and pathological events, including immune system regulation, body weight control, pigmentation, myelinization, and tumor susceptibility. 11394875 2001
CUI: C0028754
Disease: Obesity
Obesity
0.020 Biomarker disease BEFREE The mahogany protein is a receptor involved in suppression of obesity. 10086355 1999
CUI: C0023520
Disease: Leukodystrophy
Leukodystrophy
0.010 Biomarker disease BEFREE ATRN can now be added to the growing list of genes associated with hypomyelinating leukodystrophy. 28493104 2017
CUI: C0574083
Disease: 3-Methylglutaconic aciduria type 2
3-Methylglutaconic aciduria type 2
0.010 Biomarker disease BEFREE Phenotypic breadth and variability present a major challenge to the diagnostician: some children with BTHS have never been neutropenic, whereas others lack increased 3-MGCA and a minority has occult or absent CM. 23398819 2013
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.010 Biomarker group BEFREE Phenotypic breadth and variability present a major challenge to the diagnostician: some children with BTHS have never been neutropenic, whereas others lack increased 3-MGCA and a minority has occult or absent CM. 23398819 2013
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome
0.010 Biomarker disease BEFREE We identified three novel missense and one splice site variant in the PCDHA3, WWC2, ATRN, and FAT2 genes that segregated with RLS in the family. 23192925 2012
CUI: C0574084
Disease: 3-Methylglutaconic aciduria type 3
3-Methylglutaconic aciduria type 3
0.010 GeneticVariation disease BEFREE 3-Methylglutaconic aciduria type III (3-MGCA type III), caused by recessive mutations in the 2-exon gene OPA3, is characterized by early-onset bilateral optic atrophy, later-onset extrapyramidal dysfunction, and increased urinary excretion of 3-methylglutaconic acid and 3-methylglutaric acid. 20350831 2010
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.010 Biomarker disease BEFREE We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) and skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 870 common controls. 19384953 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.010 Biomarker disease BEFREE We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) and skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases and 870 common controls. 19384953 2009
CUI: C0004114
Disease: Astrocytoma
Astrocytoma
0.010 AlteredExpression disease BEFREE To independently validate these results, we examined attractin expression in a new set of 108 normal and tumoral brain tissue specimens and found elevated expression in 97% of malignant astrocytomas, with the highest levels in grade 4 tumors. 17085642 2006
CUI: C0334579
Disease: Anaplastic astrocytoma
Anaplastic astrocytoma
0.010 Biomarker disease BEFREE Among 60 cerebrospinal fluid samples of patients with various central nervous system diseases, attractin was consistently found to be elevated in the samples of patients with malignant astrocytoma. 17085642 2006