FOXN1, forkhead box N1, 8456

N. diseases: 60; N. variants: 5
Disease: DiGeorge Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 GeneticVariation disease BEFREE Thymic hypoplasia/aplasia occurs as a part of DiGeorge syndrome, which has several known genetic causes, and with loss-of-function mutations in forkhead box N1 (FOXN1). 31600545 2020
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 GeneticVariation disease BEFREE The mice with the Foxn1 compound heterozygous mutations had thymic hypoplasia, causing a T-B+NK+ SCID phenotype, whereas the hair and nails of these mice were normal. 31566583 2019
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 AlteredExpression disease BEFREE Our findings illustrate the complexities of the early steps of thymopoiesis and indicate that sporadic forms of thymic hypoplasia in humans may result from the interaction of genes affecting the magnitude of BMP signalling and Foxn1 expression. 28819138 2017
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 Biomarker disease MGD T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. 15141078 2004
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 Biomarker disease MGD Thymus dysgenesis in nude (nu nu) mice. 5493276 1970
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 Biomarker disease MGD The lymphoid tissues in mice with congenital aplasia of the thymus. 5784127 1969
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 Biomarker disease MGD Absence of thymus in a mouse mutant. 5639157 1968
CUI: C0012236
Disease: DiGeorge Syndrome
DiGeorge Syndrome 		0.230 Biomarker disease MGD 'Nude', a new hairless gene with pleiotropic effects in the mouse. 5980117 1966