GLIS2, GLIS family zinc finger 2, 84662

N. diseases: 67; N. variants: 2
Disease: Leukemogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.050 GeneticVariation disease BEFREE Several members of the NKL subclass are deregulated in T-cell progenitors and support leukemogenesis. 30308041 2018
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.050 Biomarker disease BEFREE ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network. 28292433 2017
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.050 AlteredExpression disease BEFREE However, since the expression of CBFA2T3-GLIS2 fusion in mice is not sufficient for leukemogenesis, we speculated that further unknown abnormalities could contribute to both cancer transformation and response to treatment. 24127550 2013
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.050 Biomarker disease BEFREE All eight NKL genes posses a conserved Eh1 repressor motif, which has an important role in regulating downstream targets in hematopoiesis and possibly in leukemogenesis as well. 22094586 2012
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.050 AlteredExpression disease BEFREE These data suggest that expression of CBFA2T3-GLIS2 directly contributes to leukemogenesis. 23153540 2012