INSM2, INSM transcriptional repressor 2, 84684

N. diseases: 11; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 AlteredExpression disease BEFREE Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the E-boxes of the insulinoma-associated 2 (Insm2) gene promoter, thereby activating the expression of Insm2 in insulin-secretion cells. 30359270 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 Biomarker disease BEFREE Risk factors for rapid development of diabetes in this young population were FDR status and initial positivity for GADA, IA-2, and IAA or a combination of GADA and IAA. 24034790 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 GeneticVariation disease BEFREE We assessed diabetes risk associated with zinc transporter-8 antibodies (ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 diabetes with the standard biochemical autoantibodies (BAA) to insulin (IAA), GAD65 (GAD65A), and/or insulinoma-associated protein 2 antigen (IA-2A). 22446173 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 Biomarker disease BEFREE Autoantibody-negative patients were retested at median diabetes duration of 3.2 yr (range 0.9-16.2) for autoantibodies (GAD, IA2, ZnT8), human leukocyte antigen (HLA) typing, non-fasting C-peptide, and sequencing of HNF4A, HNF1A, KCNJ11, and INS. 21518407 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 Biomarker disease BEFREE The aim of the study was to investigate the use of hyperglycaemic clamp tests to identify individuals who will develop diabetes among insulinoma-associated protein-2 antibody (IA-2A)-positive first-degree relatives (IA-2A(+) FDRs) of type 1 diabetic patients. 19898832 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 GeneticVariation disease BEFREE They were detected in 55 of 128 (43%) children with autoantibodies to insulin, GAD and/or insulinoma-associated protein 2 and 34 of 42 (81%) who progressed to diabetes. 19590848 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 Biomarker disease BEFREE Neither GAD- nor IA2-specific TCRs mediated T-cell islet infiltration or diabetes even though T-cells developed in these Rg mice and responded to their cognate epitope. 18299317 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.080 Biomarker disease BEFREE Crystal structure of the major diabetes autoantigen insulinoma-associated protein 2 reveals distinctive immune epitopes. 17192463 2007