|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Hereditary catalase deficiencies and increased risk of diabetes.
|
11117918 |
2000 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catalase gene mutations have been detected in association with diabetes mellitus, hypertension, and vitiligo.
|
15771551 |
2004 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Detection of a novel familial catalase mutation (Hungarian type D) and the possible risk of inherited catalase deficiency for diabetes mellitus.
|
15800961 |
2005 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Detection of a novel familial catalase mutation (Hungarian type D) and the possible risk of inherited catalase deficiency for diabetes mellitus.
|
15800961 |
2005 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.
|
17577741 |
2007 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.
|
17577741 |
2007 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catalase (CAT) is a major antioxidant enzyme and a number of polymorphisms in the CAT have been described as being associated with several diseases, such as hypertension, diabetes mellitus, Alzheimer's disease, and vitiligo.
|
18353692 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus.
|
18423055 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
(i) to determine the extent of oxidative stress and DNA damage and repair using a panel of selected markers in patients with type 1 and type 2 diabetes mellitus (T1DM, T2DM), (ii) to find their possible relationships with diabetes compensation and duration, and finally (iii) to test for the effect of functional polymorphisms in the 8-oxoguanin DNA glycosylase (rs1052133), catalase (rs1001179) and superoxide dismutase (rs4880) genes on respective intermediate phenotypes.
|
21338322 |
2011 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Whatever impaired glucose tolerance, insulin resistance on diabetes and whatever their occurrence or implications, the studies taken together converge toward the hypothesis that catalase polymorphisms play a role in glucose disorders.
|
22617568 |
2012 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Effects of rs769217 and rs1001179 polymorphisms of catalase gene on blood catalase, carbohydrate and lipid biomarkers in diabetes mellitus.
|
22712453 |
2012 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Rats were studied 30 days after the STZ treatment, and the diabetes untreated model group presented significantly higher kidney index, blood glucose, triglyceride (TG), total cholesterol (TC), malondialdehyde (MDA), interferon-γ (IFN-γ), and IFN-γ/IL-4 levels, lower body weight, fasting blood insulin (FPI), IL-4, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and nitric oxide (NO) levels and worse renal function (higher blood urea nitrogen (BUN), serum creatinine (SCr), urine protein (UP) levels and glomerular extracellular matrix (relative area)) compared with the normal control group (p < 0.05).
|
24595557 |
2014 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The high (18.5%) prevalence of diabetes mellitus in inherited catalase deficient individuals and the earlier (10 years) manifestation of the disease may be attributed to the oxidative damage of oxidant sensitive, insulin producing pancreatic beta-cells.
|
24025477 |
2014 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Decrease in Sirtuin1 (SIRT1) and nuclear factor erythroid 2-related factor (Nrf2) and increase in nuclear factor kappa B (NFκB) gene expression in diabetes were associated with a decrease in CAT and GPx mRNA expression.
|
24740756 |
2014 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Catalase (CAT) is a major antioxidant enzyme and a number of polymorphisms in CAT have been shown to be associated with several diseases, including hypertension, diabetes mellitus, Alzheimer's disease, and vitiligo.
|
24817970 |
2014 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to examine association of decreased blood catalase activity and catalase exon mutations in patients (n=617) with diabetes (n=380), microcytic anemia (n=58), beta-thalassemia (n=43) and presbycusis (n=136) and in controls (n=295).
|
25772105 |
2015 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The increase in total nitrite/nitrotyrosine in DM promoted significant compensatory increases in antioxidant activities of SOD, catalase and glutathione peroxidase/reductase probably to prevent cardiac oxidative damage.
|
27992114 |
2017 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
L. rhamnosus NCDC 17 improved oral glucose tolerance test, biochemical parameters (fasting blood glucose, plasma insulin, glycosylated haemoglobin, free fatty acids, triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol), oxidative stress (thiobarbituric acid reactive substance and activities of catalase, superoxide dismutase and glutathione peroxidase in blood and liver), bifidobacteria and lactobacilli in cecum, expression of glucagon like peptide-1 producing genes in cecum, and adiponection in epididymal fat, while decreased propionate proportions (%) in caecum, and expression of tumour necrosis factor-α and interlukin-6 in epididymal fat of diabetic rats as compared to diabetes control group.
|
28008783 |
2017 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In patients with impaired glucose regulation and diabetes, the number of coronary artery branches with stenosis and the Gensini scores were inversely correlated with the plasma levels of CAT, SOD, GSH, GH, and GSH-Px (P < 0.001).
|
27075629 |
2017 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The effect of CE extract administration on the redox status of RBCs was evaluated by assessing lipid peroxidation, the ratio of reduced/oxidized glutathione (GSH/GSSG), the level of S-glutathionylated proteins (GSSP) and the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in RBCs four weeks after diabetes onset.
|
28323046 |
2017 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Serum catalase and insulin levels, body weight and blood glucose levels (BGL), alpha-glucosidase inhibition, lipid peroxidation and glycated hemoglobin (HbA1c) were measured to evaluate both alloxan-induced diabetes mellitus and diabetic painful neuropathy (DPN).
|
29234979 |
2017 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Induction of diabetes was associated with a marked reduction in glutathione (GSH) levels; decreased activities of GSH peroxidase (GSH Px), manganese superoxide dismutase (MnSOD) and catalase; increased reactive oxygen species (ROS) levels and iNOS activity in plasma and lymphoid organs.
|
28129627 |
2017 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Studies suggest that acatalasemic individuals (i.e., those with very low catalase activity) have a higher risk for the development of diabetes.
|
27939935 |
2017 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Un-controlled diabetes weakened anti-oxidant system by decreasing SOD and CAT enzymes activities and increasing MDA production.
|
29274590 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The early NAC treatment in DM rats reduced proteinuria, creatinine, urea, TBARS and iNOS and, increased creatinine clearance, NO and eNOS, increasing significantly the antioxidant defenses, promoting elevated catalase and glutathione compared to DM-E group, all p < 0.05.
|
29778909 |
2018 |